Proof-of-concept about the role of dietary agents in the inhibition and prevention of carcinogenesis and metastasis: Focus on animal model studies
Sabitaliyevich U.Y. Aizat M. Zhanar O. Romero M.A.
3 March 2025Marmara University
Journal of Research in Pharmacy
2025#29Issue 1436 - 444 pp.
The field of nutrigenomics has gained considerable limelight and interdisciplinary researchers have started to realize its significance as a goldmine for the discovery of pathways that are important as dietary targets. Emerging evidence has provided wealth of exciting proof-of-concept studies highlighting an important role in the elucidation of oncogenic signaling cascades that can be pharmacologically targeted by dietary agents, whole extracts and isolated compounds for the inhibition/prevention of carcinogenesis and metastasis. In this review, we have critically analyzed some of the mechanistic animal models studies which have rationally propelled the field in a frontward direction. We also provide an overview of the fruits-mediated anti-metastatic effects in metastasis models that highlight how nutrigenomics may be combined with pharmacological therapies for synergistic effects, potentially ushering a path towards precision nutrition for cancer.
Apoptosis , Cancer , Cell signaling , Metastasis , Nutrigenomics
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Scientific Center for Innovative Technologies and Research, Kazakhstan
Department of Healthcare of Zhambyl region in Kazakhstan, Kazakhstan
Facultad de Medicina, Universidad Autónoma de Guerrero, Laboratorio de Investigación Clínica, Guerrero, Acapulco, Mexico
Scientific Center for Innovative Technologies and Research
Department of Healthcare of Zhambyl region in Kazakhstan
Facultad de Medicina
10 лет помогаем публиковать статьи Международный издатель
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