Prognosis of PCI in the Older Adult Population: Outcomes From the Multicenter Prospective e-ULTIMASTER Registry

Saada M. Kobo O. Kauer F. Sakhov O. Laanmets P. Abhaichand R. Lozano I. Crowley J. Wander G.S. Mamas M.A. Roguin A.
1 September 2022 Elsevier B.V.

Journal of the Society for Cardiovascular Angiography and Interventions
2022 #1 Issue 5

Background: Older adult patients undergoing percutaneous coronary intervention (PCI) are usually excluded from clinical trials. This study aimed to assess 1-year clinical outcomes in patients aged >80 years. Methods: This all-comer registry included patients who underwent PCI using the Ultimaster stent. Primary clinical endpoint was target lesion failure (TLF), a composite of cardiac death (CD), target vessel–related myocardial infarction (TV-MI), or clinically indicated target lesion revascularization (CD-TLR). Results: In total, 3286 (8.8%) patients aged ≥80 years were compared with 33,912 patients aged <80 years. The older adult patients included more women, had more comorbidities and exhibited more complex coronary anatomy. The incidence of TLF was higher in the older adult group (5.6% vs 3.0%, P <.0001), as well as for all-cause mortality (6.2% vs 1.7%, P <.0001), CD (3.3% vs 1.1%, P <.0001), and TV-MI (1.7% vs 0.8%, P <.0001), but not for CD-TLR (1.9% vs 1.7%, P =.15). After the inverse propensity score weighted analysis, aged ≥80 years was associated with increased risk of TLF (HR, 1.42; 95% CI, 1.22-1.66; P <.0001), CD (HR, 1.67; 95% CI, 1.136-2.06; P <.0001), and TV-MI (HR, 1.66; 95% CI, 1.24-2.24; P <.001) but not for CD-TLR (HR, 1.10; 95% CI, 0.85-1.43; P =.45). Conclusion: Older adult patients had a higher incidence of TLF, CD, and TV-MI but with no difference in the incidence of recurrent revascularization or stent thrombosis. Although PCI in older adults is relatively safe, higher rates of cardiac events should be considered.

age , coronary artery disease , elderly , older adults , outcome , stent , vascular disease

Text of the article Перейти на текст статьи

Hillel Yaffe Medical Center, Technion–Faculty of Medicine, Israel
Department of Cardiology, Albert Schweitzer Ziekenhuis, the Netherlands, Dordrecht, Netherlands
Department of Interventional Cardiology, City Heart Center, Almaty, Kazakhstan
Department of Cardiology, North Estonia Medical Centre, Tallinn, Estonia
Department of Cardiology, L.R.G. Naidu Cardiology Research Institute and Clinic, Kuppuswamy Naidu Memorial Hospital, Coimbatore, India
Department of Cardiology, Hospital Cabueñes, Gijon, Spain
Galway University Hospital, Galway, Ireland
Hero DMC Heart Institute, Dayanand Medical College, Punjab, Ludhiana, India
Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele, United Kingdom

Hillel Yaffe Medical Center
Department of Cardiology
Department of Interventional Cardiology
Department of Cardiology
Department of Cardiology
Department of Cardiology
Galway University Hospital
Hero DMC Heart Institute
Keele Cardiovascular Research Group

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026