Comprehensive Overview of Innovative Strategies in Preventing Renal Ischemia-reperfusion Injury: Insights from Bibliometric and In silico Analyses
Rysmakhanov M.S. Zare A. Smagulov A.S. Abenova N.A. Mussin N.M. Sultangereyev Y.B. Zhakiyev B.S. Kuttymuratov G.K. Haberal M. Jafari N. Baneshi H. Bakhshalizadeh S. Mahdipour M. Rahmanifar F. Tamadon A.
2024Bentham Science Publishers
Current Pharmaceutical Design
2024#30Issue 201578 - 1598 pp.
Background: Ischemia-reperfusion Injury (IRI) is a complex pathophysiological process with severe consequences, including irreversible loss of renal function. Various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and kidney reperfusion. Aim: This comprehensive analysis provides an overview of pharmacological agents and intraoperative methods for preventing and treating renal IRI. Methods: Our analysis revealed that eplerenone exhibited the highest binding affinity to crucial targets, including Aldehyde Dehydrogenase (AD), Estrogen Receptor (ER), Klotho protein, Mineralocorticoid Receptor (MR), and Toll-like Receptor 4 (TLR4). This finding indicates eplerenones potential as a potent preventive agent against IRI, surpassing other available therapeutics like Benzodioxole, Hydrocortisone, Indoles, Nicotinamide adenine dinucleotide, and Niacinamide. In preventing kidney IRI, our comprehensive analysis emphasizes the significance of eplerenone due to its strong binding affinity to key targets involved in the pathogenesis of IRI. Results: This finding positions eplerenone as a promising candidate for further clinical investigation and consideration for future clinical practice. Conclusion: The insights provided in this analysis will assist clinicians and researchers in selecting effective preventive approaches for renal IRI in surgical settings, potentially improving patient outcomes.
bibliometric analysis , Ischemia-reperfusion injury , kidney reperfusion , kidney transplantation , molecular docking , renal resection
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Department of Surgery and Urology No. 2, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
Department of Surgery and Transplantation, Aktobe Medical Center, Aktobe, Kazakhstan
PerciaVista R&D Co, Shiraz, Iran
Department of General Medical Practice No. 1, West Kazakhstan Medical University, Aktobe, Kazakhstan
Department of General Surgery, Division of Transplantation, Başkent University, Ankara, Turkey
Reproductive Development, Murdoch Childrens Research Institute, Melbourne, VIC, Australia
Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Department for Scientific Work, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
Department of Surgery and Urology No. 2
Department of Surgery and Transplantation
PerciaVista R&D Co
Department of General Medical Practice No. 1
Department of General Surgery
Reproductive Development
Department of Paediatrics
Stem Cell Research Center
Department of Applied Cell Sciences
Department of Basic Sciences
Department for Scientific Work
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