Helicobacter pylori eradication therapy for children
Rysbekov K. Abrakhmanova S. Satybaeva R. Starosvetova Y. Kushugulova A.
1 June 2024Walter de Gruyter GmbH
Drug Metabolism and Personalized Therapy
2024#39Issue 259 - 67 pp.
Objectives: The research aims to investigate the effect of vitamin D supplementation on the efficacy of Helicobacter pylori eradication therapy and to find new drug combinations for the eradication of the bacterium. Methods: A total of 128 children participated in the research. They were distributed under the following criteria: group A were children who tested positive for H. pylori and were treated with the standard so-called triple therapy including vitamin D; group B were children who tested positive for H. pylori and received the standard triple therapy without including vitamin D in the treatment; and group C were children who tested negative for H. pylori. After endoscopic examination, additional venous blood samples were taken from the children to determine vitamin D levels. A controlled study was carried out 45 days after the initial treatment. Results: The overall success rate of eradication therapy was 84.1 %. In group A, the success rate of treatment was 93.5 %, contrary to group B, where the success rate was 75 %. Although there was a difference in the percentage of H. pylori eradication therapy in the main group compared to the control group, there was no significant difference in group B. The success rate of eradication is p=0.082. Conclusions: Following the research results, the addition of vitamin D to the standard triple therapy regimen for H. pylori had no effect. It can therefore be concluded that vitamin D does not significantly increase the efficacy of eradication therapy.
antibiotic , bacteria , plan , resistance , vitamin D
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Department of Pediatric, Diseases with Courses Cardio-Rheumatology and Gastroenterology, Astana Medical University, Astana, Kazakhstan
Laboratory of Human Microbiome and Longevity, National Laboratory Astana, Astana, Kazakhstan
Department of Pediatric
Laboratory of Human Microbiome and Longevity
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