Personalized IVF preparation in women of advanced reproductive age: Cohort study results
Rybina A.N. Abshekenova A.T. Askar E. Karibaeva S.K. Valiev R.K.
1 July 2025Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2025#2025Issue 292 - 101 pp.
Relevance: Despite the widespread implementation of modern assisted reproductive technologies (ART), global infertility rates remain consistently high. One of the key factors limiting the success of ART is the increasing reproductive age of female patients. As a woman ages, the likelihood of conception naturally declines, significantly worsening ART outcomes. Therefore, patients of advanced reproductive age require more detailed and comprehensive preparation for ART and a well-defined medical care algorithm. The study aimed to assess the effectiveness of a preparation algorithm for patients of advanced reproductive age undergoing in vitro fertilization (IVF) programs. Materials and Methods: A prospective cohort study was conducted from January to December 2023. The study included two groups of patients: the main group, consisting of 30 women who underwent individualized preconception preparation, and the control group of 39 women who received the standard examination and preparation protocol before undergoing IVF and embryo transfer. A training algorithm adapted for the Kazakh population has been developed and tested. Results: The patient groups were comparable in age and anamnesis. In both groups, the genetic markers of folate metabolism did not differ from the general population. The average numbers and quality of oocytes and blastocysts were comparable. The pregnancy rate was at 63.3% in the main group vs. 43.6% among the controls (p < 0.05); the live birth rate was 46.67% vs. 23.1% (p = 0.040). The pregnancy loss rate amounted to 47.1% among the controls, three times higher than in the main group (15.8%, p = 0.043). Conclusion: Personalizing the preparation of women of advanced reproductive age for ART improves the efficiency of ART programs by increasing the likelihood of pregnancy and live births while reducing reproductive losses. The molecular genetic methods further increase the selection accuracy of embryos with high implantation potential.
advanced reproductive age , ART outcomes , infertility , preconception preparation
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“PERSONA” International Clinical Center for Reproductology, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
“PERSONA” International Clinical Center for Reproductology
Asfendiyarov Kazakh National Medical University
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