Modern methods of introduction of patients with poor ovarian response to controlled ovarian stimulation: A literature review
Rybina A.N. Kemel А.B. Valiev R.К. Аskar Y. Tanysheva G.A. Ellenbogen A.
31 December 2024Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2024#2024Issue 49 - 18 pp.
Relevance: Poor ovarian response to controlled ovarian stimulation is a serious problem that occurs during in vitro fertilization and embryo transfer procedures. Many women undergoing controlled ovarian stimulation may suffer from a poor ovarian response (POR), and currently its frequency tends to increase in young patients. Among women who receive controlled ovarian stimulation, the frequency of POR reached 9%-24%. The study aimed to determine the effectiveness and safety of regimens including adjuvant therapy with controlled ovarian stimulation with POR. Materials and Methods: Literature search was performed on all types of clinical trials in Russian and English, according to the following keywords and phrases related to the topic methods of introduction of patients with poor ovarian response: poor ovarian response, adjuvant therapy, Poseidon group, controlled ovarian stimulation, assisted reproduction technology. The review used scientific databases such as PubMed, Scopus, Web of Science and Google Scholar. The criteria for selecting literature included relevance (publications devoted to this topic no older than 10 years) and relevance of research to the topic of the review, as well as the availability of full texts of articles. Results: Comparison of ovarian response to adjuvant therapy with an alternative stimulation protocol, in some cases adjuvant therapy showed better results. Conclusion: This review shows that the proposed strategies and pharmaceutical methods for the treatment of POR significantly increased the number of eggs extracted during the ovarian cycle, the number of viable embryos, or live birth rates. These results indicate that additional adjuvant treatment (DHEA, Coenzyme Q10) during controlled ovarian stimulation is the optimal method of management of patients with POR.
adjuvant therapy , assisted reproduction technology , controlled ovarian stimulation , poor ovarian response , POSEIDON (Patient-Oriented Strategies Encompassing Individualized Oocyte Number)
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“PERSONA” International Clinical Center for Reproductology, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Semey Medical University NCJSC, Semey, Kazakhstan
Hillel Yaffe Medical Center, Hadera, Israel
“PERSONA” International Clinical Center for Reproductology
Asfendiyarov Kazakh National Medical University
Semey Medical University NCJSC
Hillel Yaffe Medical Center
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