The mechanistic role of NAT10 in cancer: Unraveling the enigmatic web of oncogenic signaling
Rodrigues P. Bangali H. Ali E. Nauryzbaevish A.S. Hjazi A. Fenjan M.N. Alawadi A. Alsaalamy A. Alasheqi M.Q. Mustafa Y.F.
January 2024Elsevier GmbH
Pathology Research and Practice
2024#253
N-acetyltransferase 10 (NAT10), a versatile enzyme, has gained considerable attention as a significant player in the complex realm of cancer biology. Its enigmatic role in tumorigenesis extends across a wide array of cellular processes, impacting cell growth, differentiation, survival, and genomic stability. Within the intricate network of oncogenic signaling, NAT10 emerges as a crucial agent in multiple cancer types, such as breast, lung, colorectal, and leukemia. This compelling research addresses the intricate complexity of the mechanistic role of NAT10 in cancer development. By elucidating its active participation in essential physiological processes, we investigate the regulatory role of NAT10 in cell cycle checkpoints, coordination of chromatin remodeling, and detailed modulation of the delicate balance between apoptosis and cell survival. Perturbations in NAT10 expression and function have been linked to oncogenesis, metastasis, and drug resistance in a variety of cancer types. Furthermore, the bewildering interactions between NAT10 and key oncogenic factors, such as p53 and c-Myc, are deciphered, providing profound insights into the molecular underpinnings of cancer pathogenesis. Equally intriguing, the paradoxical role of NAT10 as a potential tumor suppressor or oncogene is influenced by context-dependent factors and the cellular microenvironment. This study explores the fascinating interplay of genetic changes, epigenetic changes, and post-translational modifications that shape the dual character of NAT10, revealing the delicate balance between cancer initiation and suppression. Taken together, this overview delves deeply into the enigmatic role of NAT10 in cancer, elucidating its multifaceted roles and its complex interplay with oncogenic networks.
Cancer , NAT10 , Oncogenic factors , Tumor suppressor , Tumorigenesis
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Department of Computer Engineering, College of Computer Science, King Khalid University, Al-Faraa, Saudi Arabia
College of Chemistry, Al-Zahraa University for Women, Karbala, Iraq
Institute of Genetics and Physiology SC MSHE RK, Laboratory of Physiology Lymphatic System, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq
College of Technical Engineering, the Islamic University, Najaf, Iraq
College of Technical Engineering, the Islamic University of Al Diwaniyah, Iraq
College of Technical Engineering, the Islamic University of Babylon, Iraq
College of Technical Engineering, Imam Jaafar Al-Sadiq University, Al-Muthanna, 66002, Iraq
College of Nursing, National University of Science and Technology, Dhi Qar, Iraq
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq
Department of Computer Engineering
College of Chemistry
Institute of Genetics and Physiology SC MSHE RK
Department of Medical Laboratory Sciences
College of Health and Medical Technology
College of Technical Engineering
College of Technical Engineering
College of Technical Engineering
College of Technical Engineering
College of Nursing
Department of Pharmaceutical Chemistry
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