Association of 3 single nucleotide polymorphisms of the eighth chromosome with remodeling of the myocardium and carotid arteries in the Kazakh population

Raushan K. Benberin V. Vochshenkova T. Babenko D. Sibagatova A.
12 February 2021 Lippincott Williams and Wilkins

Medicine (United States)
2021 #100 Issue 6 E24608 pp.

Cardiovascular diseases are one of the key health issues in Kazakhstan. According to the WHO, the prevalence of arterial hypertension (AH) was 28% in males and 25% in females in 2015, which puts up vastly to premature mortality from non-communicable diseases.The search for genetic features of target organ lesions processes in AH is relevant. The goal of this study was to search for the genetic markers of myocardial remodeling (MR) and carotid artery remodeling (CAR).A total of 866 hypertensive individuals were recruited in Nur-Sultan, Kazakhstan. Their blood was genotyped for 9 single nucleotide polymorphisms (SNPs) of the eighth chromosome to find an association with remodeling. The analysis was carried out in the group pairs (control and CAR, control and MR, and control and CAR and MR). The genotype-phenotype association was assessed using 5 different inheritance models: dominant, codominant, recessive, overdominant, and log-additive.Statistically significant results were found for 3 SNPs (rs2407103, rs11775334, rs2071518) which minor alleles enlarged risks of MR and CAR in AH in the studied population. Three polymorphisms have previously been associated with АН and some other traits like pulse pressure and blood glucose in other ethnic populations: rs2407103 - in Afro-American population, rs11775334 - in the European population, rs2071518 is well studied in various ethnic populations (European, South Asian, Afro-American, Hispanic, East Asian). Copyright

carotid artery remodeling , carotid artery thickness , Kazakh , left ventricular hypertrophy , myocardial remodeling , single nucleotide polymorphisms

Text of the article Перейти на текст статьи

Medical Centre Hospital of Presidents Affairs Administration of the Republic of Kazakhstan, Kazakhstan
Karaganda Medical University, Kazakhstan

Medical Centre Hospital of Presidents Affairs Administration of the Republic of Kazakhstan
Karaganda Medical University

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026