Green synthesis and biomedicinal applications of silver and gold nanoparticles functionalized with methanolic extract of Mentha longifolia
Rauf A. Ahmad T. Khan A. Maryam Uddin G. Ahmad B. Mabkhot Y.N. Bawazeer S. Riaz N. Malikovna B.K. Almarhoon Z.M. Al-Harrasi A.
2021Taylor and Francis Ltd.
Artificial Cells, Nanomedicine and Biotechnology
2021#49Issue 1194 - 203 pp.
This study deals with facile and rapid synthesis of silver nanoparticles (AgNPs) and Gold nanoparticles (AuNPs) using Mentha longifolia leaves extracts (MLE). The synthesized AgNPs and AuNPs were characterized by UV-visible spectroscopy (UV-Vis), Fourier transformed infra-red spectroscopy (FT-IR), atomic force microscopy (AFM) and transmission electron microscopy (TEM) techniques. The phytochemical analysis showed the presence of bioactive secondary metabolites, which are involved in the synthesis of nanoparticles (NPs). The surface plasmon resonance (SPR) observed at 435 and 550 nm, confirmed the green synthesis of AgNPs and AuNPs, respectively. The TEM images showed poly dispersed and round oval shapes of Ag and Au NPs with an average particles size of 10.23 ± 2 nm and 13.45 ± 2 nm, respectively. TEM results are in close agreements with that of AFM analysis. The FT-IR spectroscopy revealed the presence of OH, –NH2 and C = O groups, which involved in the synthesis of NPs. The MLE and their AgNPs and AuNP exhibited good in vitro antibacterial and anti-oxidant activities. Moreover, MLE and NPs also showed in vivo analgesic activities in mice, and excellent sedative properties in open field test paradigm.
AgNPs , analgesic , antibacterial , antioxidant , AuNPs , Green synthesis , sedative
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Department of Chemistry, University of Swabi Anbar, Khyber Pakhtunkhwa, Pakistan
Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman
Institute of Chemical Sciences, University of Peshawar, Peshawar, KPK, Pakistan
Centre for Biotechnology & Microbiology, University of Peshawar, Peshawar, Pakistan
Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
Research Center for Advanced Materials Sciences (RCAMS), King Khalid University, Abha, Saudi Arabia
Pharmacognosy Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia
Department of Environmental Sciences, COMSATS University Islamabad, Abbottabad Campus, Islamabad, Pakistan
Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
Department of Chemistry
Natural and Medical Sciences Research Center
Institute of Chemical Sciences
Centre for Biotechnology & Microbiology
Department of Pharmaceutical Chemistry
Research Center for Advanced Materials Sciences (RCAMS)
Pharmacognosy Department
Department of Environmental Sciences
Department of Chemistry and Chemical Technology
Department of Chemistry
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