The role of genetic variations in metabolic syndrome: insights into etiology, diagnosis, and management
Rao D.S. Kumar A. Agarwal S. Elshaikh R.H. Choudhary A. Choudhary R.K. Babker A.M.A. Rathore R. Nurmakhanova Z. Nurgaliyeva Z. Musayev A. Sah A.K.
2025Page Press Publications
Italian Journal of Medicine
2025#19Issue 1
Metabolic syndrome (MetS) is a cluster of interrelated conditions primarily driven by excessive caloric intake, physical inactivity, and excess abdominal fat. Core features include abdominal obesity, insulin resistance, dyslipidemia, and elevated blood pressure. MetS is also closely associated with several comorbidities, such as a prothrombotic state, systemic inflammation, nonalcoholic fatty liver disease, and reproductive abnormalities. Its global prevalence is rising rapidly, particularly in urbanized areas and developing nations, reflecting changing lifestyles and dietary patterns. This surge has significant public health implications, as individuals with MetS face a twofold higher risk of developing cardiovascular diseases and a fivefold increased likelihood of progressing to type 2 diabetes. Managing MetS requires a multifaceted approach, with lifestyle modification as the cornerstone. Sustainable weight loss, achieved through dietary changes, regular physical activity, and behavioral interventions, is essential. Concurrently, it is critical to address other cardiovascular risk factors aggressively, including hypertension, hyperlipidemia, and hyperglycemia, to mitigate long-term health complications. As the prevalence of MetS continues to grow, understanding its pathophysiology and implementing comprehensive management strategies are paramount to reducing its global burden and improving patient outcomes.
abdominal obesity , cholesterol , diabetes , metabolic syndrome , polymorphism
Text of the article Перейти на текст статьи
Department of Medical Laboratory Technology, School of Allied Health Sciences, Galgotias University, Uttar Pradesh, Greater Noida, India
School of Biological and Life Sciences, Galgotias University, Uttar Pradesh, Dankaur, India
School of Allied Health Sciences, Galgotias University, Uttar Pradesh, Greater Noida, India
Department of Medical Laboratory Science, College of Applied Health Sciences, A’ Sharqiyah University, Ibra, Oman
School of Allied Health Science, Noida International University, Uttar Pradesh, Greater Noida, India
Departent of Medical Laboratory Technology, Amity Medical, Amity University Haryana, Haryana, Gurugram, India
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates
Department of General Medicine, Kazakh National Medical University, Almaty, Kazakhstan
Department of Pediatrics, Kazakh National Medical University, Almaty, Kazakhstan
Department of Emergency and First Aid, Kazakh National Medical University, Almaty, Kazakhstan
Department of Medical Laboratory Technology
School of Biological and Life Sciences
School of Allied Health Sciences
Department of Medical Laboratory Science
School of Allied Health Science
Departent of Medical Laboratory Technology
Department of Medical Laboratory Sciences
Department of General Medicine
Department of Pediatrics
Department of Emergency and First Aid
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026