Prevention of cancer therapy-related cardiac dysfunction and heart failure in cancer patients and survivors. A Clinical Consensus Statement of the Heart Failure Association, the European Association of Preventive Cardiology of the ESC, and the ESC Council of Cardio-Oncology
Rakisheva A. Farmakis D. Attanasio A. Genis A.B. Cohen-Solal A. Gulati G. Halle M. Hill L. Fernandez T.L. Lyon A.R. Moura B. Santoro C. Tocchetti C.G. van Linthout S. Vassiliou V. Sener Y.Z. Bekbosynova M. Metra M. Rosano G. Piepoli M.
November 2025John Wiley and Sons Ltd
European Journal of Heart Failure
2025#27Issue 112084 - 2099 pp.
Despite advances in cancer treatments with significant improvement in patient outcomes, chemotherapy, targeted molecular therapies and radiotherapy may cause a range of cardiovascular complications, such as cancer therapy-related cardiac dysfunction (CTRCD), which represents a broad spectrum of possible presentation and aetiological link with the broad scope of various cancer therapies, including chemotherapy, targeted agents, immunotherapies, and radiation therapy, aiming at reducing the associated morbidity and mortality. However, practical guidelines on the primary prevention of CTRCD in high-risk patients, a key element in improving prognosis, are lacking in cancer patients and related evidence remains inconclusive. This Clinical Consensus Statement, authored by experts from the Heart Failure Association (HFA) and the European Association of Preventive Cardiology (EAPC) of the European Society of Cardiology (ESC), and the ESC Council of Cardio-Oncology, aims to discuss the definition and epidemiology of CTRCD, the implicated factors for risk stratification, and the appropriate early diagnostic pathways, while focusing on lifestyle modifications, and pharmacological interventions to reduce the incidence of CTRCD. In addition, a holistic cardio-oncology management approach is advised for prevention and long-term management.
Cancer patients and survivors , Cancer therapy-related cardiac dysfunction , Heart failure prevention
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City Cardiology Center, Almaty, Kazakhstan
Heart Failure and Cardio-Oncology Unit, Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School, Athens, Greece
Cardiology University Department, IRCCS Policlinico San Donato, Milan, Italy
Heart Institute, Hospital Universitari Germans Trias i Poujol, Badalona, Spain
Universite Paris Cite, INSEM U942, Cardiology Department, Lariboisiere Hospital, AP-HP, Paris, France
Division of Medicine, Department of Cardiology, Oslo University Hospital, Oslo, Norway
K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
Department of Preventive Sports Medicine and Sports Cardiology, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich, Munich, Germany
School of Nursing and Paramedic Science, Ulster University, Londonderry, United Kingdom
Cardiology Department, La Paz University Hospital, IdiPAZ Research Institute, Madrid, Spain
Cardiology Department, Hospital Universitario Quironsalud, Madrid, Spain
Cardio-Oncology Centre of Excellence, Royal Brompton Hospital, London, United Kingdom
Armed Forces Hospital, Porto, Portugal
Faculty of Medicine of University of Porto, Porto, Portugal
Department of Advanced Biomedical Science, Federico II University, Naples, Italy
Department of Translational Medical Sciences (DISMET), Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy
BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin, Berlin, Germany
Norwich Medical School, University of East Anglia and Norfolk and Norwich University Hospital, Norwich, United Kingdom
Department of Cardiology, Thoraxcentrum, Erasmus MC, Rotterdam, Netherlands
UMC, Astana, Kazakhstan
ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
Department of Human Sciences and Promotion of Quality of Life, Chair of Pharmacology, San Raffaele University of Rome, Rome, Italy
IRCCS San Raffaele, Rome, Italy
Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
City Cardiology Center
Heart Failure and Cardio-Oncology Unit
Cardiology University Department
Heart Institute
Universite Paris Cite
Division of Medicine
K.G. Jebsen Center for Cardiac Biomarkers
Department of Preventive Sports Medicine and Sports Cardiology
School of Nursing and Paramedic Science
Cardiology Department
Cardiology Department
Cardio-Oncology Centre of Excellence
Armed Forces Hospital
Faculty of Medicine of University of Porto
Department of Advanced Biomedical Science
Department of Translational Medical Sciences (DISMET)
BIH Center for Regenerative Therapies (BCRT)
Norwich Medical School
Department of Cardiology
UMC
ASST Spedali Civili di Brescia
Department of Human Sciences and Promotion of Quality of Life
IRCCS San Raffaele
Department of Biomedical Sciences for Health
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