New Mechanisms of Barretts Esophagus Development
Rakhmetova V. Aldabergenova A. Beisenbekova A. Kalimullina M. Temirbek M.
2024National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2024#21Issue 320 - 25 pp.
Barretts esophagus (BE) is a pathological condition that develops as a result of metaplastic transformation of the stratified squamous nonkeratinized epithelium of the mucous membrane of the distal part of esophagus into columnar epithelium of the intestinal type. The purpose of this review was to investigate novel hypotheses and mechanisms related to the development of BE, aiming to identify emerging trends and enhance understanding of the diseases pathogenesis for the purpose of preventing esophageal adenocarcinoma. A thorough investigation of recent scholarly publications was carried out to examine the mechanisms contributing to the development of BE. In the process of scrutinizing an extensive array of literature, novel pathways involving cell transdifferentiation and transcommitment were elucidated, supplementing the conventional theory of esophageal cell replacement. Many aspects remain unclear, especially concerning the cell population from which BE originates and the molecular processes or phases involved in its progression to esophageal adenocarcinoma. These questions hold immense importance for researchers, as the answers will profoundly influence efforts in disease prevention and treatment. Although there are presently few experimental model systems accessible for the study of BE and esophageal adenocarcinoma, advancements in tissue engineering and organotypic cell culture systems utilizing human cells present promising avenues for future research into the pathogenesis and advancement of these conditions.
Barretts esophagus , Barretts metaplasia , esophageal cell differentiation , esophageal dysplasia , gastroesophageal reflux disease
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Department of Internal Medicine, NJSC “Astana Medical University”, Astana, Kazakhstan
Gastroenterology residency, NJSC “Astana Medical University”, Astana, Kazakhstan
Department of Internal Medicine
Gastroenterology residency
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