Fiber-optic semi-distributed Fabry-Perot interferometer for low-limit label-free detection of CCL5 cancer biomarker

Rakhimbekova A. Seitkamal K. Kudaibergenov B. Nazir F. Pham T. Blanc W. Vangelista L. Tosi D.
January 2024 Elsevier Ltd

Optics and Laser Technology
2024 #168

We present an optical fiber label-free biosensor based on a partially stochastic Fabry-Perot interferometer for the detection of CCL5 (CC Chemokine Ligand 5) cancer biomarker. The sensor has a very simple fabrication process, with a splice-and-cleave approach that requires only one splice and a subsequent cleave at the fiber tip. The enhanced backscattering within the Mg-NP fiber paired with the Fresnel reflection at the fiber tip forms a low-finesse interferometric structure; the inner reflections due to Rayleigh scattering provide an additional layers of phase shifts, forming a semi-distributed interferometer (SDI). The average sensitivity of the SDI sensors has been reported to be 92.5 dB/RIU. Sensors were biofunctionalized for the purpose of detecting CCL5 by means of a silanization process. We report the detection of CCL5 in diluted serum with a sensitivity of 2.947 mRIU for each 10-fold concentration increase and a limit of detection of 17.6 aM.

Cancer biomarker detection , CCL5 , Enhanced Rayleigh backscattering , Fabry-Perot interferometry , Optical fiber biosensors , Single-mode fibers

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Department of Electrical and Computer Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana, Kazakhstan
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
Université Côte dAzur, INPHYNI, CNRS UMR7010, 17 rue Julien Lauprêtre, Nice, 06200, France
Department of Molecular Medicine, University of Pavia, Pavia, Italy
Laboratory of Biosensors and Bioinstruments, National Laboratory Astana, Astana, Kazakhstan

Department of Electrical and Computer Engineering
Department of Biomedical Sciences
Department of Biology
Université Côte dAzur
Department of Molecular Medicine
Laboratory of Biosensors and Bioinstruments

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