Well designed iridium-phosphinite complexes: Biological assays, electrochemical behavior and density functional theory calculations
Rafikova K. Meriç N. Binbay N.E. Okumuş V. Erdem K. Belyankova Y. Tursynbek S. Dauletbakov A. Bayazit S. Zolotareva D. Yerassyl K. Güzel R. Ocak Y.S. Aydemir M.
5 October 2024Elsevier B.V.
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
2024#318
Mononuclear phosphinite Iridium complexes based on ferrocene group have been prepared and characterized by various spectroscopic techniques. The complexes were subjected to cyclic voltammetry studies in order to determine the energies of HOMO and LUMO levels and to estimate their electrochemical and some electronic properties. Organic complex-based memory substrates were immobilized using TiO2-modified ITO electrodes, and the memory functions of phosphinite-based organic complexes were verified by chronoamperometry (CA) and open-circuit potential amperometry (OCPA). Extensive theoretical and experimental investigations were directed to gain a more profound understanding of the chemical descriptors and the diverse electronic transitions taking place within the iridium complexes, as well as their electrochemical characteristics. The quantum chemical calculations were carried out for the iridium complexes at the DFT/CAM-B3LYP level of theory in the gas phase. Furthermore, the antioxidant, antimicrobial, DNA binding, and DNA cleavage activities of the complexes were tested. Complex 2 exhibited the highest radical scavenging activity (67.5 ± 2.24 %) at 200.0 mg/L concentration. It was observed that the complexes formed an inhibition zone in the range of 8–15 mm against Gram + bacteria and in the range of 0–13 mm against Gram – bacteria. The agarose gel electrophoresis method was used to determine the DNA binding and DNA cleavage activities of the complexes. All of the tested complexes had DNA binding activity; however, complexes 1, 2, and 8 showed better binding activity than the others.
Biological assays , DFT calculation , Electrochemical behavior , Ferrocene group , Iridium , Phosphinite ligand
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Satbayev University, Institute of Chemical and Biological Technologies, Almaty, Kazakhstan
Kazakh-British Technical University, School of Chemical Engineering, Almaty, Kazakhstan
Dicle University, Faculty of Science, Department of Chemistry, Diyarbakir, 21280, Turkey
Dicle University, Technical Vocational School, Department of Hair Care and Beauty Services, Diyarbakir, 21280, Turkey
Dicle University, Technical Vocational School, Department of Electronics, Diyarbakir, 21280, Turkey
Siirt University, Faculty of Medicine, Department of Medical Biology, Siirt, 56100, Turkey
Siirt University, Instution of Science, Department of Biology, Siirt, 56100, Turkey
Dicle University, Faculty of Education, Department of Science, Diyarbakir, 21280, Turkey
Institute of Nanotechnology, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan
Satbayev University
Kazakh-British Technical University
Dicle University
Dicle University
Dicle University
Siirt University
Siirt University
Dicle University
Institute of Nanotechnology
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