Role of DNA Methyltransferases (DNMTs) in metastasis
Qureshi M.Z. Sabitaliyevich U.Y. Rabandiyarov M. Arystanbekuly A.T.
2022Cellular and Molecular Biology Association
Cellular and Molecular Biology
2022#68Issue 1226 - 236 pp.
The DNA methyltransferase (DNMT) family constitutes a conserved set of DNA-modifying enzymes which have essential functions in the modulation of epigenetics. The fundamental role of epigenetic changes in carcinogenesis and metastasis is increasingly being appreciated. DNMTs (DNMT1, DNMT3A and DNMT3B) have been shown to drive metastasis. Epigenetic machinery is installed at the target sites for the regulation of a wide variety of genes. Moreover, microRNAs, long non-coding RNAs and circular RNAs also shape the epigenetic landscape during metastasis. In this review, we have provided a snapshot of the quintessential role of DNMTs in metastasis. We also summarize how lncRNAs and circRNAs play roles in the epigenetic regulation of a myriad of genes.
Apoptosis , Cancer , Epigenetics , Metastasis , Signaling
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Deanship of Educational Services, Department of Biochemistry, Qassim University, Buraydah, Saudi Arabia
Scientific Center for Innovative Technologies and Research, Kazakhstan
Department of Neurosurgery, City Childrens Clinical Hospital N°2, Almaty, Kazakhstan
Semey Medical University, Kazakhstan
Deanship of Educational Services
Scientific Center for Innovative Technologies and Research
Department of Neurosurgery
Semey Medical University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026