The role of zygotic genome activation in genetic−related reproductive medicine: Technological perspective, religious and bioethical concerns, challenges and benefits
Qasim N.H. Zhumagaliuly A. Khozhamkul R. Rahim F.
March 2024Elsevier B.V.
Journal of Genetic Engineering and Biotechnology
2024#22Issue 1
Zygotic Genome Activation (ZGA) is a crucial developmental milestone in early embryogenesis, marking the transition from maternal to embryonic control of development. This process, which varies in timing across species, involves the activation of the embryonic genome, paving the way for subsequent cell differentiation and organismal development. Recent advances in genomics and reproductive medicine have highlighted the potential of ZGA in the realm of genetic screening, providing a window into the genetic integrity of the developing embryo at its earliest stages. The intersection of ZGA and genetic screening primarily emerges in the context of preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). These techniques, often employed during assisted reproductive technologies, aim to detect potential genetic abnormalities or chromosomal imbalances before embryo implantation. Given that ZGA represents the onset of embryonic gene expression, understanding its intricacies can significantly enhance the accuracy and predictive power of these screening processes. With the advent of next-generation sequencing and other high-throughput genomic techniques, detailed mapping of the transcriptomic changes during ZGA has become feasible. Such advancements have deepened our insights into the dynamics of early embryonic development and the onset of genetic disorders. As our knowledge in this realm expands, it promises to revolutionize our capabilities in detecting, understanding, and potentially rectifying genetic anomalies at the earliest stages of human life, thereby optimizing reproductive outcomes.
Assisted Reproductive Technologies , Embryogenesis , Genetic Screening , Preimplantation Genetic Diagnosis (PGD) , Preimplantation Genetic Screening (PGS) , Reproductive Medicine , Zygotic Genome Activation (ZGA)
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Cihan University Sulaimaniya Research Center (CUSRC), Cihan University - Sulaimaniya, Kurdistan Region, 46001, Iraq
Department of Public Health, Asfendiyarov Kazakh National Medical University, Kazakhstan
Department of Biostatistics and Basics of Research, Asfendiyarov Kazakh National Medical University, Kazakhstan
Department of Health Policy and Public Health, Al-Farabi Kazakh National University, Kazakhstan
College of Health Sciences, Cihan University-Sulaimaniya, Kurdistan Region, Iraq
Cihan University Sulaimaniya Research Center (CUSRC)
Department of Public Health
Department of Biostatistics and Basics of Research
Department of Health Policy and Public Health
College of Health Sciences
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