Precise monitoring of transpulmonic resistance in bridge-to-transplant patients supported by the Aeson total artificial heart
Pya Y. Bekbossynova M. Medressova A. Latremouille C. Jansen P. Tauyekelova A. Kaliyev R. Jetybayeva S. Ziegler L.A. Rajapreyar I. Eduardo Rame J.
July 2025Elsevier Inc.
Journal of Heart and Lung Transplantation
2025#44Issue 71161 - 1164 pp.
The Aeson total artificial heart (TAH) features embedded pressure sensors for flow autoregulation, which can also be used to estimate pressure gradients. In this bridge-to-transplant study, right and left ventricular pressure data and pump output from the TAH were analyzed to estimate transpulmonic resistance (eTPR) every 30 days. Three patients (aged 60, 35, and 54) with preimplant pulmonary vascular resistance of 7.0, 3.2, and 7.1 Wood Units, respectively, were supported by the TAH at pump outputs of 4.5 to 6.5 liter/min. All showed significant eTPR reductions (1.4-1.5 Wood Units) and received donor hearts after 243, 155, and 109 days of support. Two patients underwent successful transplants without complications; one died post transplant from pneumonia and multiorgan failure. The Aeson TAHs eTPR monitoring system offers a promising, noninvasive approach to managing pulmonary hypertension and assessing transplant eligibility in real time.
automatic monitoring , bioprosthetic artificial heart , bridge to candidacy , pulmonary arterial hypertension
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Division of Cardiac Surgery, University Medical Center, Astana, Kazakhstan
University Medical Center, Heart Center, Astana, Kazakhstan
Carmat SA, Vélizy, France
University of Pittsburgh Medical Center, Procirca Mechanical Circulatory Support, Pittsburgh, PA, United States
Division of Cardiology, Tufts Medical Center, Boston, Massachusetts, United States
Jefferson Bruce and Robbi Toll Heart and Vascular Institute, Sidney Kimmel College of Medicine, Philadelphia, Pennsylvania, United States
Division of Cardiac Surgery
University Medical Center
Carmat SA
University of Pittsburgh Medical Center
Division of Cardiology
Jefferson Bruce and Robbi Toll Heart and Vascular Institute
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