Preloaded combination nicotine replacement therapy for smoking cessation in Kazakhstan: A randomized controlled trial study protocol
Purushothama C. Crape B.L. Stolyarov V. Jaxybayeva A. La Fleur P. Olickal J.J.
November 2023Public Library of Science
PLoS ONE
2023#18Issue 11 November
Background Tobacco use is a major cause of premature death and disease in Kazakhstan, with over 22,500 deaths per year. Although efforts have been made to control tobacco use, smokingrelated deaths have continued to increase. One strategy to help smokers quit is to use nicotine replacement therapy (NRT), with combination NRT resulting in higher long-term quit rates than a single form of NRT. A study aims to determine the effectiveness of preloaded combination NRT on smoking cessation, the change in health-related quality of life due to smoking cessation, and explore treatment adherence perceptions. Methods and analysis The study will be conducted as a randomized, single-blind superiority trial, with 100 participants in each arm. The trial will be carried out at the National Research Cardiac Surgery Center, Astana, Kazakhstan, and will recruit current smokers aged 18 years and above with a motivation to quit. Participants will be randomly allocated to either the intervention group or the control group. The former will receive preloaded combination NRT, while the latter will receive fast-acting NRT alone. The primary outcome measure will be sustained abstinence from smoking after six months. Secondary outcome measures will include health-related quality of life and adherence to the treatment. Discussion The study may gather further evidence that a combination NRT is more efficient than a fastacting NRT alone. The findings of this study may help to improve tobacco cessation strategies in Kazakhstan and other countries with high smoking prevalence rates. Copyright:
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School of Sciences & Humanities, Nazarbayev University, Nur-Sultan city, Kazakhstan
Nazarbayev University School of Medicine, Nur-Sultan city, Kazakhstan
Astana Medical University, Astana, Kazakhstan
Department of Medicine, Nazarbayev University School of Medicine, Astana, Kazakhstan
Department of Public Health, Amrita Institute of Medical Sciences, Kerala, Kochi, India
School of Sciences & Humanities
Nazarbayev University School of Medicine
Astana Medical University
Department of Medicine
Department of Public Health
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