Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies
Prudinnik D.S. Kussanova A. Vorobjev I.A. Tikhonov A. Ataullakhanov F.I. Barteneva N.S.
June 2025International Society on Aging and Disease
Aging and Disease
2025#16Issue 31242 - 1264 pp.
Aging is interrelated with changes in red blood cell parameters and functionality. In this article, we focus on red blood cells (RBCs) and provide a review of the known changes associated with the characterization of RBC deformability in aging and related pathologies. The biophysical parameters complement the commonly used biochemical parameters and may contribute to a better understanding of the aging process. The power of the deformability measurement approach is well established in clinical settings. Measuring RBCs deformability has the advantage of relative simplicity, and it reflects the complex effects developing in erythrocytes during aging. However, aging and related pathological conditions also promote heterogeneity of RBC features and have a certain impact on the variance in erythrocyte cell properties. The possible applications of deformability as an early biophysical biomarker of pathological states are discussed, and modulating PIEZO1 as a therapeutic target is suggested. The changes in RBCs shape can serve as a proxy for deformability evaluation, leveraging single-cell analysis with imaging flow cytometry and artificial intelligence algorithms. The characterization of biophysical parameters of RBCs is in progress in humans and will provide a better understanding of the complex dynamics of aging.
Aging , Alzheimer’s Disease , Cellular deformability , Erythrocytes , Imaging flow cytometry , Neurodegenerative diseases , Parkinson Disease , PIEZO1 , Yoda1
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Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, PA, United States
Department of Biology
Department of Physiology
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