Plasma 25-Hydroxyvitamin D Level and VDR Gene Single Nucleotide Polymorphism rs2228570 Influence on COVID-19 Susceptibility among the Kazakh Ethnic Group—A Pilot Study

Protas V.V. Pogossyan G.P. Li K.G. Zhumina A.G. Bisseneva A.K. Shaikina D.N.
April 2023 MDPI

Nutrients
2023 #15 Issue 7

Low plasma levels of the vitamin D metabolite 25-hydroxyvitamin D [25(OH)D] and the vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) have been associated with the body’s susceptibility to infectious diseases, including COVID-19. In this pilot retrospective study, representatives of the Kazakh population (central Kazakhstan) were divided into groups based on the test for IgM and IgG for coronavirus infection. We compared the 25(OH)D plasma levels and concluded that the COVID-19-positive group values (25.17 ng/mL ± 16.65) were statistically lower (p = 0.0114) compared to the COVID-19-negative ones (35.58 ng/mL ± 20.67). There was no association between age, gender and 25(OH)D concentration within the groups (p > 0.05). The genotyping of rs2228570 was performed using a TaqMan Real-Time PCR assay. Allele C predominated among the COVID-19-negative participants and significantly reduced the likelihood of coronavirus infection (p < 0.0001; OR = 0.0804; 95% CI 0.02357–0.2798). There were no statistically significant differences in the frequencies of the A, G and T alleles in the studied groups (p > 0.05). The GG genotype of rs2228570 was associated with a 4.131-fold increased likelihood of COVID-19 infection (p = 0.0288; χ² = 5.364; OR = 4.131; 95% CI 1.223–13.71). Comprehensive studies are required to determine whether low 25(OH)D plasma concentrations and genetic background represent a risk factor for COVID-19 infection.

25(OH)D , COVID-19 , genetic polymorphism rs2228570 , susceptibility , vitamin D , vitamin D receptor (VDR) gene

Text of the article Перейти на текст статьи

Department of Botany, Karaganda Buketov University, Karaganda, 100028, Kazakhstan
Biotechnology and Eco-Monitoring Research Park, Karaganda Buketov University, Karaganda, 100028, Kazakhstan
Department of Biology, Non-Profit Limited Company “Manash Kozybayev North Kazakhstan University”, Petropavlovsk, 150000, Kazakhstan

Department of Botany
Biotechnology and Eco-Monitoring Research Park
Department of Biology

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026