Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
Prasher P. Sharma M. Singh S.K. Gulati M. Chellappan D.K. Rajput R. Gupta G. Ydyrys A. Kulbayeva M. Abdull Razis A.F. Modu B. Sharifi-Rad J. Dua K.
2023Frontiers Media S.A.
Frontiers in Chemistry
2023#11
Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties. Spermidine specifically interferes with the tumour cell cycle, resulting in the inhibition of tumor cell proliferation and suppression of tumor growth. Moreover, it also triggers autophagy by regulating key oncologic pathways. The increased intake of polyamines, such as spermidine, can suppress oncogenesis and slow the growth of tumors due to its role in anticancer immunosurveillance and regulation of polyamine metabolism. Spermidine/spermine N-1-acetyltransferase (SSAT) plays a critical role in polyamine homeostasis and serves as a diagnostic marker in human cancers. Chemically modified derivatives of spermidine hold great potential for prognostic, diagnostic, and therapeutic applications against various malignancies. This review discusses in detail the recent findings that support the anticancer mechanisms of spermidine and its molecular physiology. Copyright
anticancer immunosurveillance , anticancer properties , cell proliferation , diagnostic marker , polyamines , spermidine
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Department of Chemistry, University of Petroleum and Energy Studies, Dehradun, India
Department of Chemistry, Uttaranchal University, Dehradun, India
School of Pharmaceutical Science, Lovely Professional University, Phagwara, India
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, Australia
School of Pharmacy, International Medical University, Bukit Jalil, Malaysia
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, Australia
School of Pharmacy, Suresh Gyan Vihar University, Rajasthan, Jaipur, India
Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Department of Biochemistry, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Chemistry
Department of Chemistry
School of Pharmaceutical Science
Faculty of Health
School of Pharmacy
Discipline of Pharmacy
School of Pharmacy
Department of Pharmacology
Biomedical Research Centre
Department of Biophysics
Department of Food Science
Natural Medicines and Products Research Laboratory
Department of Biochemistry
Facultad de Medicina
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