Solubility and Thermodynamic Studies of Mesalazine in 1,4-Dioxane + Water Binary Mixtures at Different Temperatures
Poturcu K. Rahimpour E. Jouyban A.
April 2025Springer
Journal of Solution Chemistry
2025#54Issue 4467 - 484 pp.
In the current work, the solubility studies of mesalazine were performed in 1,4-dioxane + water mixtures at five different temperatures (293.2–313.2K). The experimental solubility data were correlated with some linear and non-linear cosolvency models (i.e., the van’t Hoff, the Jouyban-Acree, and modified Wilson). The maximum solubility of mesalazine in mole fraction unit was 2.75 × 10–4 in neat 1,4-dioxane at 313.2K and the minimum solubility was 1.20 × 10–4 in water at 293.2K. The accuracy of the cosolvency models was investigated with the mean relative deviations for solubility prediction of the back-calculated solubility data against experimental values, and results showed high accuracy with MRDs% (< 9.0%). The Gibbs energy, enthalpy, and entropy were calculated utilizing the van’t Hoff and Gibbs equations. Moreover, the density values for saturated mixtures were measured and represented by the Jouyban-Acree model. This study provides, for the first time, the determination of experimental solubility data of mesalazine in 1,4-dioxane + water mixtures.
1,4-Dioxane , Cosolvency models , Mesalazine , Solubility , Thermodynamic
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Department of Chemistry, Faculty of Engineering and Natural Science, Suleyman Demirel University, Isparta, Kazakhstan
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Faculty of Pharmacy, Near East University, PO BOX:, North Cyprus, Mersin 10, Nicosia, 99138, Turkey
Department of Chemistry
Pharmaceutical Analysis Research Center and Faculty of Pharmacy
Infectious and Tropical Diseases Research Center
Faculty of Pharmacy
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