Medicinal and mechanistic overview of artemisinin in the treatment of human diseases
Posadino A.M. Giordo R. Pintus G. Mohammed S.A. Orhan I.E. Fokou P.V.T. Sharopov F. Adetunji C.O. Gulsunoglu-Konuskan Z. Ydyrys A. Armstrong L. Sytar O. Martorell M. Razis A.F.A. Modu B. Calina D. Habtemariam S. Sharifi-Rad J. Cho W.C.
July 2023Elsevier Masson s.r.l.
Biomedicine and Pharmacotherapy
2023#163
Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial infections, and some cardiovascular diseases, especially in Asia, North America, Europe and other parts of the world. This comprehensive review aims to update the biomedical potential of ART and its derivatives for treating human diseases highlighting its pharmacokinetic and pharmacological properties based on the results of experimental pharmacological studies in vitro and in vivo. Cellular and molecular mechanisms of action, tested doses and toxic effects of artemisinin were also described. The analysis of data based on an up-to-date literature search showed that ART and its derivatives display anticancer effects along with a wide range of pharmacological activities such as antibacterial, antiviral, antimalarial, antioxidant and cardioprotective effects. These compounds have great potential for discovering new drugs used as adjunctive therapies in cancer and various other diseases. Detailed translational and experimental studies are however needed to fully understand the pharmacological effects of these compounds.
Anticancer , Antimicrobial , Antioxidant , Artemisinin , Pharmacological mechanisms , Safety profile
Text of the article Перейти на текст статьи
Department of Biomedical Sciences, University of Sassari, Viale San Pietro, Sassari, 07100, Italy
Department of Medical Laboratory Sciences, College of Health Sciences, and Sharjah Institute for Medical Research, University of Sharjah, University City Rd, Sharjah, 27272, United Arab Emirates
Center for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh, 15213, PA, United States
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, 06330, Turkey
Turkish Academy of Sciences (TÜBA), Vedat Dalokay Cad., No. 112, Ankara, 06670, Turkey
Department of Biochemistry, Faculty of Science, University of Bamenda, P.O. Box. 39, Bambili, Cameroon
V.I. Nikitin Chemistry Institute of the National Academy of Sciences of Tajikistan, Ayni 299/2, Dushanbe, 734063, Tajikistan
Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Edo State University Uzairue, Iyamho, Edo State, Auchi, PMB 04, Nigeria
Faculty of Health Science, Nutrition and Dietetics Department, Istanbul Aydin University, Istanbul, 34295, Turkey
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi ave. 71, Almaty, 050040, Kazakhstan
State University of Ponta Grossa, Departament of Pharmaceutical Sciences, Paraná, Ponta Grossa, 84030900, Brazil
Federal University of Paraná, Department of Pharmacy, Paraná, Curitiba, 80210170, Brazil
Institute of Plant and Environmental Sciences, Slovak Agricultural University in Nitra, Nitra, 94976, Slovakia
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, 4070386, Chile
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Serdang, 43400, UPM, Malaysia
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Serdang, 43400, UPM, Malaysia
Department of Biochemistry, Faculty of Science, University of Maiduguri, Borno State, Maiduguri, 1069, Nigeria
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Pharmacognosy Research & Herbal Analysis Services UK, University of Greenwich, Central Avenue, Chatham-Maritime, Kent, ME4 4TB, United Kingdom
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Department of Biomedical Sciences
Department of Medical Laboratory Sciences
Center for Ultrasound Molecular Imaging and Therapeutics
Department of Pharmacognosy
Turkish Academy of Sciences (TÜBA)
Department of Biochemistry
V.I. Nikitin Chemistry Institute of the National Academy of Sciences of Tajikistan
Applied Microbiology
Faculty of Health Science
Biomedical Research Centre
State University of Ponta Grossa
Federal University of Paraná
Institute of Plant and Environmental Sciences
Department of Nutrition and Dietetics
Universidad de Concepción
Department of Food Science
Natural Medicines and Products Research Laboratory
Department of Biochemistry
Department of Clinical Pharmacy
Pharmacognosy Research & Herbal Analysis Services UK
Facultad de Medicina
Department of Clinical Oncology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026