Clinical case: acute on chronic liver failure (ACLF)
Poperezhaeva K.I. Rakhmetova V.S. Abai G.A.
2022LLC MMA MediaMedika
Clinical Review for General Practice
2022#3Issue 445 - 47 pp.
Acute-on-chronic liver failure (ACLF) is an acute liver disorder manifested as jaundice (serum bilirubin levels ≥5 mg/dL) and coagulopathy (INR ≥1.5 or prothrombin activity < 40%), complicated by ascites and/or encephalopathy within 4 weeks, that is found in patients with the previously diagnosed or undiagnosed chronic liver disease. ACLF is a serious medical issue worldwide. The ACLF pathogenesis is based on the pronounced systemic inflammatory response to pathogenic antigens and biological structures produced during the liver cell death, with subsequent immune paralysis and multiple organ failure. Acute-on-chronic liver failure (ACLF) may develop at any stage, from compensated to decompensated cirrhosis; the disorder may involve both hepatic and extrahepatic precipitating events. drug treatment of ACLF includes early detection and treatment of the precipitating factor and maintenance therapy. It has been proven that treatment of the trigger at an early stage reduces mortality, however, the management of ACLF is focused mostly on the maintenance therapy. ACLF belongs to the syndromes seldom diagnosed in clinical practice, that is why the ACLF case study is of special interest. The paper reports a confirmed case of ACLF.
acute-on-chronic liver failure , ascites , coagulopathy , hepatic cirrhosis , jaundice , portal hypertension
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Astana medical university, Astana, Kazakhstan
Astana medical university
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026