Mycoplasma pneumoniae Seroprevalence and Total IgE Levels in Patients with Juvenile Idiopathic Arthritis

Poddighe D. Abdukhakimova D. Dossybayeva K. Mukusheva Z. Assylbekova M. Rakhimzhanova M. Ibrayeva A. Mukash G. Tuleutayev Y.
2021 Hindawi Limited

Journal of Immunology Research
2021 #2021

Background. Mycoplasma pneumoniae (M. pneumoniae) is implicated in several immune-mediated extrapulmonary manifestations, including reactive arthritis. Recently, increased total serum IgE were reported in children developing M. pneumoniae-related extrapulmonary diseases (MpEPDs). Here, we aimed at analyzing these aspects in children affected with rheumatic disorders and, in detail, Juvenile Idiopathic Arthritis (JIA). Methods. M. pneumoniae serology (IgG and IgM) and total serum IgE were concomitantly analyzed in 139 pediatric patients diagnosed with: JIA (Group 1, n=85), or any rheumatic disease other than JIA (Group 2, n=27), or non-inflammatory endocrinological disorders (Group 3, n=27). Results. Overall, 19.4% M. pneumoniae seroprevalence was observed in this hospitalized pediatric population, without signicant differences among the three groups. No significant differences in total serum IgE levels were noted among these groups; however, a second analysis excluding children with very high (and clearly abnormal) IgE levels suggested that JIA patients and, in detail, those with oligopolyarticular forms may have higher serum IgE concentrations. This relative difference among groups in serum IgE level seems to be more pronounced in M. pneumoniae seropositive children. Conclusions. M. pneumoniae infection should be actively sought in children developing immune-mediated diseases, including patients affected with JIA and, especially, in oligopolyarticular forms. There is some evidence that total serum IgE levels may tend to be increased in patients with oligopolyarticular JIA subtype and especially in those resulting as M. pneumoniae seropositive. However, further and focused research is needed to confirm these preliminary results and to clarify the relation between M. pneumoniae infection, atopic status, and immune-mediated arthritis.

Text of the article Перейти на текст статьи

Department of Medicine, Nazarbayev University, School of Medicine, Nur-Sultan, Kazakhstan
Clinical Academic Department of Pediatrics, National Research Center for Maternal and Child Health, Nur-Sultan, Kazakhstan

Department of Medicine
Clinical Academic Department of Pediatrics

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026