HLA-B*51 allelic and carrier frequency in Kazakhstan: insights into Behçet’s disease prevalence in Central Asia

Poddighe D. Turganbekova A. Mukusheva Z. Abdirakhmanova A. Assylbekova M. Abdrakhmanova S.
March 2021 Springer Science and Business Media Deutschland GmbH

Internal and Emergency Medicine
2021 #16 Issue 2 325 - 331 pp.

Behçet’s disease (BD) is a systemic vasculitis whose prevalence varies according to the ethnicity. HLA-B*51 is a well-known genetic factor predisposing to BD: populations with higher HLA-B*51 allelic frequencies are also those with a greater disease prevalence, as occurs in the Silk Road countries. However, the BD prevalence is unknown in many countries, including Kazakhstan and, in general, Central Asia, despite the location on or near the Silk Road. Due to the lack of clinical studies from this area, we analyzed the bone marrow donors registry in Kazakhstan, in order to assess the HLA-B*51 allelic and carrier frequencies, which resulted to be 8.14 and 15.28%, respectively. Through a comparison with the same parameters in other countries (by performing a data search in the medical literature and in the Allele Frequency Net Database), we might speculate a BD prevalence in Kazakhstan of 10–15/100.000 at least. This result should prompt a greater clinical consideration of this disease in Central Asia, as well as the publication of clinical data from this geographic area.

Allelic frequency , Behçet’s disease , Central Asia , HLA-B*57 , Kazakhstan , Prevalence

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Department of Medicine, Nazarbayev University School of Medicine, Kerei-Zhanibek Str. 5/1, Nur-Sultan, 010000, Kazakhstan
RSE on REM Scientific-Production Center of Transfusion Medicine, Ministry of Health of the Republic of Kazakhstan, Nur-Sultan, Kazakhstan
Department of Pediatric Rheumatology, National Research Center for Mother and Child Health, University Medical Center, Nur-Sultan, Kazakhstan

Department of Medicine
RSE on REM Scientific-Production Center of Transfusion Medicine
Department of Pediatric Rheumatology

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