Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers

Poddighe D. Abdukhakimova D.
21 May 2021 Baishideng Publishing Group Co

World Journal of Gastroenterology
2021 #27 Issue 19 2251 - 2256 pp.

Celiac Disease (CD) had been considered uncommon in Asia for a long time. However, several studies suggested that, in the Indian subcontinent and Middle East countries, CD is present and as prevalent as in Western countries. Outside these Asian regions, the information about the epidemiology of CD is still lacking or largely incomplete for different and variable reasons. Here, we discuss the epidemiological aspects and the diagnostic barriers in several Asian regions including China, Japan, Southeast Asia and Russia/Central Asia. In some of those regions, especially Russia and Central Asia, the prevalence of CD is very likely to be underestimated. Several factors may, to a different extent, contribute to CD underdiagnosis (and, thus, underestimation of its epidemiological burden), including the poor disease awareness among physicians and/or patients, limited access to diagnostic resources, inappropriate use or interpretation of the serological tests, absence of standardized diagnostic and endoscopic protocols, and insufficient expertise in histopathological interpretation. © 2021 The Author(s). Published by Baishideng Publishing Group Inc. All rights reserved.

Asia , Celiac disease , Central Asia , China , Diagnostic barriers , Epidemiology , HLA-DQB1 , Japan , Prevalence , Russia

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Department of Medicine, School of Medicine, Nazarbayev University, Kerei-Zhanibek Str. 5/1, Nur-Sultan, 010000, Kazakhstan
Clinical Academic Department of Pediatrics, Research Center for Maternal and Child Health, University Medical Center, Nur-Sultan, 010000, Kazakhstan

Department of Medicine
Clinical Academic Department of Pediatrics

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