Autoimmune pancreatitis and pancreatic cancer: Epidemiological aspects and immunological considerations
Poddighe D.
7 July 2021Baishideng Publishing Group Co
World Journal of Gastroenterology
2021#27Issue 253825 - 3836 pp.
Ordinary chronic pancreatitis is a well-known risk factor for pancreatic cancer, whereas such an association with autoimmune pancreatitis (AIP) is widely debated. Due to the rarity of the latter disorder, there are few specific clinical and epidemiological studies investigating the relation between AIP and pancreatic cancer, which do not seem to support it. However, these studies are affected by several limitations and, therefore, a link between AIP (and, specifically, type 1 AIP) and pancreatic cancer cannot be ruled out definitively on this basis. Moreover, several immunopathological aspects of type 1 AIP and, in general, immunoglobulin G4-related disease can create an immunological context that may impair the tumoral immunosurveillance and promote the pancreatic carcinogenesis and its progression. In detail, Th2 immunological dominance, type 2 macrophage polarization and basophil infiltration observed in type 1 AIP, may play a permissive role in creating a favorable immunological environment for pancreatic carcinogenesis, in addition to the immunosuppressive therapies that can be used in these patients.
Autoimmune pancreatitis , Basophils , Chronic pancreatitis , Epidemiology , Immunoglobulin G4-related disease , Immunology , Macrophages , Pancreatic cancer , Systemic lupus erythematosus , Th2 cells
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Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department of Pediatrics, National Research Institute for Maternal and Child Health (NRCMCH), University Medical Center (UMC), Nur-Sultan, 010000, Kazakhstan
Department of Medicine
Department of Pediatrics
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