Daily and Weekly “High Doses” of Cholecalciferol for the Prevention and Treatment of Vitamin D Deficiency for Obese or Multi-Morbidity and Multi-Treatment Patients Requiring Multi-Drugs—A Narrative Review
Pludowski P. Marcinowska-Suchowierska E. Togizbayev G. Belaya Z. Grant W.B. Pilz S. Holick M.F.
August 2024Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients
2024#16Issue 15
Daily vitamin D supplementation using higher than normal dosing (up to the upper limit value) and intermittent (once or twice per week) dosing were studied in patients with increased risk of vitamin D deficiency. Using a PubMed database, a thorough search for published randomized controlled trials and other studies was conducted, and the results were analyzed. This review provides an overview of the use of 7000 IU daily, 30,000 IU per week or twice weekly, and 50,000 IU weekly of vitamin D for obtaining and maintaining 25(OH)D concentrations of at least 30 ng/mL in patients at high risk of vitamin D deficiency. The abovementioned dosages should be considered in adults with obesity, liver disease or malabsorption syndromes, or multi-diseased patients, mainly seniors requiring multi-drug treatment, including drugs affecting vitamin D metabolism. The simple schedules of 7000 IU/day, 30,000 IU/week or twice weekly, and 50,000 IU/week for use by patients with an increased risk of vitamin D deficiency were provided for consideration. Without monitoring of 25(OH)D, daily doses of 7000 IU or intermittent doses of 30,000 IU/week should be considered for a prolonged time as prophylactic or maintenance doses, mainly in obese patients, patients with liver disease and patients with malabsorption syndromes. For the treatment of possible vitamin D deficiency without assessment of 25(OH)D in these groups, intermittent doses of 30,000 IU twice weekly or 50,000 IU per week should be considered for a 6–8-week period only. The higher daily doses or the intermittent doses suggested above are effective, safe and responsive based on patient’s preferences.
30,000 IU per week , 50,000 IU per week , 7000 IU per day , effectiveness , intermittent doses , safety , vitamin D in high doses
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Department of Clinical Biochemistry, The Children’s Memorial Health Institute, Warsaw, 04-730, Poland
Department of Internal Medicine and Geriatric Cardiology, Medical Centre of Postgraduate Education, Warsaw, 01-813, Poland
Department of Geriatrics and Gerontology, School of Public Health, Medical Centre of Postgraduate Education, Warsaw, 01-813, Poland
Department of Rheumatology, Kazakh National Medical University, Almaty, 050000, Kazakhstan
The National Medical Research Center for Endocrinology, Moscow, 117036, Russian Federation
Nutrition and Health Research Center, San Francisco, 94109, CA, United States
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, 8036, Austria
Section Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Boston University School of Medicine, Boston, 02118, MA, United States
Department of Clinical Biochemistry
Department of Internal Medicine and Geriatric Cardiology
Department of Geriatrics and Gerontology
Department of Rheumatology
The National Medical Research Center for Endocrinology
Nutrition and Health Research Center
Department of Internal Medicine
Section Endocrinology
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