Phytates as a natural source for health promotion: A critical evaluation of clinical trials
Pires S.M.G. Reis R.S. Cardoso S.M. Pezzani R. Paredes-Osses E. Seilkhan A. Ydyrys A. Martorell M. Sönmez Gürer E. Setzer W.N. Abdull Razis A.F. Modu B. Calina D. Sharifi-Rad J.
2023Frontiers Media S.A.
Frontiers in Chemistry
2023#11
Phytates are a type of organophosphorus compound produced in terrestrial ecosystems by plants. In plant feeds, phytic acid and its salt form, phytate, account for 60%–80% of total phosphorus. Because phytate is a polyanionic molecule, it can chelate positively charged cations such as calcium, iron, and zinc. Due to its prevalence in vegetal tissues and the fact that people consume plants, phytate was first considered a potential health benefit. This updated review aims to summarize the current data on the results of clinical trials of phytates on human health, highlighting both beneficial and undesirable effects. To obtain these updated data, published papers in electronic databases such as PubMed/MedLine, TRIP database, Wiley, Google Scholar, Baidu, and Scopus were searched. Study results have shown that phytate can have beneficial health effects such as antioxidant, anticancer potential and reduction of pathological calcifications in blood vessels and organs; but also, negative effects by reducing the absorption of minerals important for maintaining the homeostasis of the human body. According to these recent results derived from recent clinical studies, phytates may be a potential natural source for health benefits. To improve clinical efficacy and human health benefits, further dose-response studies are needed to determine effective therapeutic doses and potential interactions with conventional drugs. Copyright
clinical trials , health benefits , nutrients , organophosphorus compound , phytate
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LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal
Phytotherapy Lab (PhT-Lab), Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Padova, Italy
AIROB, Associazione Italiana per la Ricerca Oncologica di Base, Padova, Italy
Instituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Las Américas, Chile
Educational Program, Geography, Environment and Service Sector, Abai Kazakh National Pedagogical University, Almaty, Kazakhstan
Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Centre for Healthy Living, Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepción, Concepción, Chile
Unidad de Desarrollo Tecnológico, UDT, Universidad de Concepción, Concepción, Chile
Department of Pharmacognosy, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey
Aromatic Plant Research Center, Lehi, UT, United States
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, United States
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Serdang, Malaysia
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Serdang, Malaysia
Department of Biochemistry, Faculty of Science, University of Maiduguri, Borno, Maiduguri, Nigeria
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
LAQV-REQUIMTE
Phytotherapy Lab (PhT-Lab)
AIROB
Instituto de Ciencias Naturales
Educational Program
Biomedical Research Centre
Centre for Healthy Living
Unidad de Desarrollo Tecnológico
Department of Pharmacognosy
Aromatic Plant Research Center
Department of Chemistry
Department of Food Science
Natural Medicines and Products Research Laboratory
Department of Biochemistry
Department of Clinical Pharmacy
Facultad de Medicina
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