Anticancer properties of bromelain: State-of-the-art and recent trends
Pezzani R. Jiménez-Garcia M. Capó X. Sönmez Gürer E. Sharopov F. Rachel T.Y.L. Ntieche Woutouoba D. Rescigno A. Peddio S. Zucca P. Tsouh Fokou P.V. Martorell M. Gulsunoglu-Konuskan Z. Ydyrys A. Bekzat T. Gulmira T. Hano C. Sharifi-Rad J. Calina D.
9 January 2023Frontiers Media S.A.
Frontiers in Oncology
2023#12
Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases. Copyright
apoptosis , bromelain , cancer , chemotherapeutics , cytotoxicity , molecular targets
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Phytotherapy Lab, Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Padova, Italy
Associazione Italiana per la Ricerca Oncologica di Base (AIROB), Padova, Italy
Laboratory of Neurophysiology, Biology Department, University of Balearic Islands (UIB), Palma de Mallorca, Spain
Research Group in Community Nutrition and Oxidative Stress and Health Research Institute of the Balearic Islands (IdISBa), University of Balearic Islands, Palma de Mallorca, Spain
Faculty of Pharmacy, Department of Pharmacognosy, Sivas Cumhuriyet University, Sivas, Turkey
Research Institution “Chinese-Tajik Innovation Center for Natural Products” of the National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan
Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon
Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde, Yaounde, Cameroon
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Department of Biochemistry, Faculty of Science, University of Bamenda, Bambili, Cameroon
Department of Nutrition and Dietetics, Faculty of Pharmacy, Centre for Healthy Living, University of Concepción, Concepción, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, Chile
Faculty of Health Science, Nutrition and Dietetics Department, Istanbul Aydin University, Istanbul, Turkey
Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan
The Elliott School of International Affairs, George Washington University, Washington, DC, United States
Department of Biodiversity and Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Biological Chemistry, University of Orleans, Chartres, France
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Phytotherapy Lab
Associazione Italiana per la Ricerca Oncologica di Base (AIROB)
Laboratory of Neurophysiology
Research Group in Community Nutrition and Oxidative Stress and Health Research Institute of the Balearic Islands (IdISBa)
Faculty of Pharmacy
Research Institution “Chinese-Tajik Innovation Center for Natural Products” of the National Academy of Sciences of Tajikistan
Institute of Medical Research and Medicinal Plants Studies (IMPM)
Antimicrobial and Biocontrol Agents Unit
Department of Biomedical Sciences
Department of Biochemistry
Department of Nutrition and Dietetics
Universidad de Concepción
Faculty of Health Science
Biomedical Research Centre
The Elliott School of International Affairs
Department of Biodiversity and Bioresources
Department of Biophysics
Department of Biological Chemistry
Facultad de Medicina
Department of Clinical Pharmacy
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