Diagnosis and classification of optic neuritis

Petzold A. Fraser C.L. Abegg M. Alroughani R. Alshowaeir D. Alvarenga R. Andris C. Asgari N. Barnett Y. Battistella R. Behbehani R. Berger T. Bikbov M.M. Biotti D. Biousse V. Boschi A. Brazdil M. Brezhnev A. Calabresi P.A. Cordonnier M. Costello F. Cruz F.M. Cunha L.P. Daoudi S. Deschamps R. de Seze J. Diem R. Etemadifar M. Flores-Rivera J. Fonseca P. Frederiksen J. Frohman E. Frohman T. Tilikete C.F. Fujihara K. Gálvez A. Gouider R. Gracia F. Grigoriadis N. Guajardo J.M. Habek M. Hawlina M. Martínez-Lapiscina E.H. Hooker J. Hor J.Y. Howlett W. Huang-Link Y. Idrissova Z. Illes Z. Jancic J. Jindahra P. Karussis D. Kerty E. Kim H.J. Lagrèze W. Leocani L. Levin N. Liskova P. Liu Y. Maiga Y. Marignier R. McGuigan C. Meira D. Merle H. Monteiro M.L.R. Moodley A. Moura F. Muñoz S. Mustafa S. Nakashima I. Noval S. Oehninger C. Ogun O. Omoti A. Pandit L. Paul F. Rebolleda G. Reddel S. Rejdak K. Rejdak R. Rodriguez-Morales A.J. Rougier M.-B. Sa M.J. Sanchez-Dalmau B. Saylor D. Shatriah I. Siva A. Stiebel-Kalish H. Szatmary G. Ta L. Tenembaum S. Tran H. Trufanov Y. van Pesch V. Wang A.-G. Wattjes M.P. Willoughby E. Zakaria M. Zvornicanin J. Balcer L. Plant G.T.
December 2022 Elsevier Ltd

The Lancet Neurology
2022 #21 Issue 12 1120 - 1134 pp.

There is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease. Epidemiological data show that, cumulatively, optic neuritis is most frequently caused by many conditions other than multiple sclerosis. Worldwide, the cause and management of optic neuritis varies with geographical location, treatment availability, and ethnic background. We have developed diagnostic criteria for optic neuritis and a classification of optic neuritis subgroups. Our diagnostic criteria are based on clinical features that permit a diagnosis of possible optic neuritis; further paraclinical tests, utilising brain, orbital, and retinal imaging, together with antibody and other protein biomarker data, can lead to a diagnosis of definite optic neuritis. Paraclinical tests can also be applied retrospectively on stored samples and historical brain or retinal scans, which will be useful for future validation studies. Our criteria have the potential to reduce the risk of misdiagnosis, provide information on optic neuritis disease course that can guide future treatment trial design, and enable physicians to judge the likelihood of a need for long-term pharmacological management, which might differ according to optic neuritis subgroups.

Text of the article Перейти на текст статьи

The National Hospital for Neurology and Neurosurgery, University College London, London, United Kingdom
Moorfields Eye Hospital, London, United Kingdom
Neuro-ophthalmology Expert Centre, Amsterdam University Medical Center, Amsterdam, Netherlands
Department of Ophthalmology, University of Sydney, Sydney, NSW, Australia
Department of Ophthalmology, University of Bern, Bern, Switzerland
Division of Neurology, Department of Medicine, Al-Amiri Hospital, Kuwait City, Kuwait
Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia
Department of Neurology, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil
Department of Ophthalmology, University Hospital Liege, University of Liège, Liège, Belgium
Department of Neurology, Slagelse and Institute of Regional Health Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
Department of Neuroradiology, St Vincents Hospital, Sydney, NSW, Australia
Department of Neuro-Ophthalmology, University of São Paulo, São Paulo, Brazil
Neuro-Ophthalmology Unit, Ibn Sina Hospital, Kuwait City, Kuwait
Department of Neurology, Medical University of Vienna, Vienna, Austria
Ufa Eye Research Institute, Ufa, Russian Federation
Neuro-Ophthalmology Unit, Emory Eye Center, Emory University, Atlanta, GA, United States
Department of Head and Neck, Université Catholique de Louvain, Brussels, Belgium
Department of Ophthalmology, Cliniques Universitaires Saint Luc, Brusseles, Belgium
Department of Neurology, Masaryk University, Brno, Czech Republic
St Annes University Hospital, Brno, Czech Republic
Department of Ophthalmology, Kursk State Medical University, Kursk, Russian Federation
The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Department of Ophthalmology, Université Libre de Bruxelles, Bruxelles, Belgium
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
College of Medicine, University of the Philippines—Philippine General Hospital, Manila, Philippines
Surgery Department of Juiz de Fora Medical School, Federal University of Juiz de Fora, Juiz de Fora, Brazil
Department of Neurology, University Mouloud Mammeri de Ttizi Ouzou, Ttizi Ouzou, Algeria
Department of Neurology, Hospital Foundation Adolphe de Rothschild, Paris, France
Department of Neurology, Hopitaux Universitaires Strasbourg, Strasbourg, France
Department of Neurology, University Clinic Heidelberg, Heidelberg, Germany
Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran
Universidad Nacional Autónoma de México, Instituto Nacional de Neurología y Neurocirugía, Centro Médico ABC, Mexico City, Mexico
Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark
Department of Neurology, Laboratory of Neuroimmunology, Stanford University School of Medicine, Palo Alto, CA, United States
Lyon Neurosciences Research Center, Lyon I University, Lyon, France
Neuro-Ophthalmology Unit, Hospices Civils de Lyon, Lyon, France
Department of Multiple Sclerosis Therapeutics, Fukushima Medical University School of Medicine, Koriyama, Japan
Department of Ophthalmology, University of Alberta, AB, Canada
Department of Neurology, Razi University Hospital, University of Tunis El Manar, Tunis, Tunisia
Department of Neurology, Hospital Santo Tomás, Panama City, Panama
Instituto Conmemorativo Gorgas de Estudios de la Salud, Universidad Interamericana de Panama, Panama City, Panama
Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Servicio de Oftalmología, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, Chile
Department of Neurology, University of Zagreb School of Medicine, Zagreb, Croatia
Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia
Eye Hospital, University Medical Centre, Ljubljana, Slovenia
Department of Neurology, Hospital Clinic of Barcelona, Barcelona, Spain
Institut dInvestigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Aga Khan University Hospital, Nairobi, Kenya
Department of Neurology, Penang General Hospital, Penang, Malaysia
Department of Neurology, Kilimanjaro Christian Medical Center (KCMC), Moshi, Tanzania
Department of Neurology, Linköping University Hospital, Linköping, Sweden
Department of Neurology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Neurology, Odense University Hospital, Odense, Denmark
Clinic of Neurology and Psychiatry for Children and Youth, Faculty of Medicine University of Belgrade, Belgrade, Serbia
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Neuro-Ophthalmology Unit at Rabin Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Multiple Sclerosis Center, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Department of Neurology, National Cancer Center, Goyang, South Korea
Eye Center, Medical Center, Medical Faculty, University of Freiburg, Germany
Vita-Salute San Raffaele University, Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, Scientific Institute San Raffaele, Milan, Italy
Department of Neurology, Hadassah Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel
Department of Paediatrics and Inherited Metabolic Disorders, Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Department of Neurology, Gabriel Touré University Hospital, Bamako, Mali
Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et NeuroInflammation, Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hôpital Neurologique Pierre Wertheimer, Bron, France
School of Medicine, University College Dublin, Dublin, Ireland
Department of Neurology, St Vincents University Hospital, Dublin, Ireland
Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal
Department of Ophthalmology, University Hospital of Martinique, Martinique, French West Indies, France
Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil
Department of Neurology, University of KwaZulu-Natal, Durban, South Africa
Department of Neuro-Ophthalmology, Instituto Paulista Da Visão, Higienópolis, Brazil
Department of Ophthalmology, Hospital Universitari de Bellvitge, LHospitalet de Llobregat, Barcelona, Spain
Department of Neurology, Prime Healthcare Group, Dubai, United Arab Emirates
Department of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan
Department of Ophthalmology, Hospital Universitario La Paz, Madrid, Spain
Department of Neurology, School of Medicine UDELAR, Montevideo, Uruguay
Department of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria
Department of Ophthalmology, University of Benin, Benin City, Nigeria
Center for Advanced Neurological Research, Nitte University, Karnataka, India
Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité- Universiätsmedizin Berlin, Berlin, Germany
Department of Ophthalmology of Ramon y Cajal Hospital, Alcala University Madrid, Madrid, Spain
Sydney Neurology, Sydney, NSW, Australia
Department of Neurology, Medical University of Lublin, Lublin, Poland
Department of General and Pediatric Ophthalmology Medical University of Lublin, Lublin, Poland
Grupo de Investigación Biomedicina, Faculty of Medicine, Fundacion Universitaria Autonoma de las Americas, Risaralda, Colombia
Department of Ophthalmology, University Hospital of Bordeaux, Bordeaux, France
Department of Neurology, Centro Hospitalar Universitário São João and Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal
Department of Ophthalmology, Hospital Clinic of Barcelona, Barcelona, Spain
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, Turkey
Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS, United States
Department of General Planning, Ho Chi Minh City Eye Hospital, Ho Chi Minh City, Viet Nam
Department of Neurology, National Paediatric Hospital Dr Juan P Garrahan, Buenos Aires, Argentina
Department of Ophthalmology, Faculty of Medicine, Ho Chi Minh City University of Medicine and Pharmacy, Hai Yen Vision Institute, Ho Chi Minh City, Viet Nam
Department of Neurology and Reflexology, The Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
Department of Neurology, Cliniques Universitaires Saint-Luc Brussels, Belgium
Neurochemistry Unit, Institute of Neuroscience, UCLouvain, Brussels, Belgium
Department of Ophthalmology, Taipei Veterans General Hospital, National Yang-Ming Chiao-Tung University School of Medicine, Taipei, Taiwan
Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany
Department of Neurology, Auckland City Hospital, Auckland, New Zealand
Department of Neurology, Ain Shams University Hospitals, Cairo, Egypt
Department of Ophthalmology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina
Department of Neurology, Department of Population Health, Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY, United States
Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Faculty of Brain Sciences, London, United Kingdom
Unité de Neurologie Inflammatoire B4, CHU Pierre-Paul Riquet/Purpan, Toulouse, France

The National Hospital for Neurology and Neurosurgery
Moorfields Eye Hospital
Neuro-ophthalmology Expert Centre
Department of Ophthalmology
Department of Ophthalmology
Division of Neurology
Department of Ophthalmology
Department of Neurology
Department of Ophthalmology
Department of Neurology
Department of Neuroradiology
Department of Neuro-Ophthalmology
Neuro-Ophthalmology Unit
Department of Neurology
Ufa Eye Research Institute
Neuro-Ophthalmology Unit
Department of Head and Neck
Department of Ophthalmology
Department of Neurology
St Annes University Hospital
Department of Ophthalmology
The Solomon H Snyder Department of Neuroscience
Department of Ophthalmology
Department of Clinical Neurosciences
College of Medicine
Surgery Department of Juiz de Fora Medical School
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurosurgery
Universidad Nacional Autónoma de México
Department of Ophthalmology
Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT)
Department of Clinical Medicine
Department of Neurology
Department of Neurology
Lyon Neurosciences Research Center
Neuro-Ophthalmology Unit
Department of Multiple Sclerosis Therapeutics
Department of Ophthalmology
Department of Neurology
Department of Neurology
Instituto Conmemorativo Gorgas de Estudios de la Salud
Department of Neurology
Servicio de Oftalmología
Department of Neurology
Department of Neurology
Eye Hospital
Department of Neurology
Institut dInvestigacions Biomediques August Pi i Sunyer (IDIBAPS)
Aga Khan University Hospital
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Department of Neurology
Clinic of Neurology and Psychiatry for Children and Youth
Department of Medicine
Neuro-Ophthalmology Unit at Rabin Medical Center
Multiple Sclerosis Center
Department of Neurology
Department of Neurology
Eye Center
Vita-Salute San Raffaele University
Department of Neurology
Department of Paediatrics and Inherited Metabolic Disorders
Department of Radiology
Department of Neurology
Service de Neurologie
School of Medicine
Department of Neurology
Centro Hospitalar de Vila Nova de Gaia/Espinho
Department of Ophthalmology
Division of Ophthalmology
Department of Neurology
Department of Neuro-Ophthalmology
Department of Ophthalmology
Department of Neurology
Department of Neurology
Department of Ophthalmology
Department of Neurology
Department of Ophthalmology
Department of Ophthalmology
Center for Advanced Neurological Research
Experimental and Clinical Research Center
Department of Ophthalmology of Ramon y Cajal Hospital
Sydney Neurology
Department of Neurology
Department of General and Pediatric Ophthalmology Medical University of Lublin
Grupo de Investigación Biomedicina
Department of Ophthalmology
Department of Neurology
Department of Ophthalmology
Department of Ophthalmology
Department of Ophthalmology and Visual Science
Department of Neurology
Department of Ophthalmology
Department of General Planning
Department of Neurology
Department of Ophthalmology
Department of Neurology and Reflexology
Department of Neurology
Neurochemistry Unit
Department of Ophthalmology
Department of Diagnostic and Interventional Neuroradiology
Department of Neurology
Department of Neurology
Department of Ophthalmology
Department of Neurology
Department of Brain Repair and Rehabilitation
Unité de Neurologie Inflammatoire B4

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026