Substrate-Controlled Three-Component Synthesis of Diverse Fused Heterocycles
Peshkov A.A. Gapanenok D. Puzyk A. Amire N. Novikov A.S. Martynova S.D. Kalinin S. Dar’in D. Peshkov V.A. Krasavin M.
4 August 2023American Chemical Society
Journal of Organic Chemistry
2023#88Issue 1510508 - 10524 pp.
A chemoselective strategy toward a variety of fused heterocyclic scaffolds relying on a three-component condensation of heterocyclic ketene aminals (HKAs) or corresponding thioaminals with aryl glyoxals and cyclic 1,3-dicarbonyl compounds has been developed and explored. Depending on the applied combination of substrates, the strategy can be tuned to provide straightforward access to imidazo[1,2-a]quinoline, pyrrolo[1,2-a]imidazole, and pyrrolo[2,1-b]thiazole frameworks.
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Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation
Nazarbayev University, Department of Chemistry, School of Sciences and Humanities, Nur-Sultan, 010000, Kazakhstan
Research Institute of Chemistry, Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Immanuel Kant Baltic Federal University, Kaliningrad, 236016, Russian Federation
Institute of Chemistry
Nazarbayev University
Research Institute of Chemistry
Immanuel Kant Baltic Federal University
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