Multinational cross-sectional study and meta-analysis on radicular grooves, C-shaped canals, and taurodontism in mandibular first premolars across 20 countries
Pertek Hatipoğlu F. Magat G. Karobari M.I. Buchanan G.D. Kopbayeva M. Taha N. Fernández-Grisales R. Bekjanova O. Luu P. Bürklein S. Mufadhal A. Petridis X. Mora M.F. Sugumaran S. Allawi S. Ivica A. Lim W.Y. Fadag A. Jagtap R. Kulczyk T. Alfirjani S. Palma P.J. Hatipoğlu Ö.
December 2025Nature Research
Scientific Reports
2025#15Issue 1
The success of root canal therapy is fully predicated upon a complete understanding of root and canal morphology and all the anatomical variations that can complicate the endodontic treatment. Of these morphological variations, taurodontism, RGs, and C-shaped canals are of note due to their implications on diagnosis, treatment planning, and endodontic success. This study aimed to investigate the prevalence and regional variations of C-shaped canals, RGs, and taurodontism across 20 countries using CBCT imaging and meta-analytic methods. A multicenter, cross-sectional study analyzed CBCT datasets from 6,000 participants (12,000 teeth) distributed equally across 20 countries. Standardized evaluation arrangements were utilized to identify RGs (RG), taurodontism, and C-shaped canals with their prevalence stratified by region, gender, and age. Statistical analyses cover subgroup comparisons, correlation studies, and sensitivity analysis using Cramer’s V. RGs had a pooled global prevalence of 20%, with high-rised rates in Africa. C-shaped canals reported a 10% global prevalence, mainly in Asia, On the Other hand taurodontism was lowest prevalent at 7%, with markable regional variability. Prominent bilateral symmetry was noticed for all features, and taurodontism showed the highest rate (98.33%). Important correlations existed among C-shaped canals, grooves, and taurodontism showing shared developmental pathways. The current study points out the significant prevalence, including anatomical variations of RGs, taurodontism, and C-shaped canals in mandibular 1st premolars, with substantial demographic and regional differences. The findings highlight the importance of perception of these features’ morphological interrelationships along with bilateral symmetry to increase diagnostic accuracy, clinical outcomes, and treatment planning.
C-shaped canals , Cone-beam computed tomography , Endodontics , Mandibular 1 st premolars , Prevalence , Taurodontism
Text of the article Перейти на текст статьи
Department of Endodontics, Recep Tayyip Erdogan University, Rize, Turkey
Department of Oral Radiology, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkey
Department of Conservative Dentistry and Endodontics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Saveetha University, Tamil Nadu, Chennai, 600077, India
Department of Odontology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
School of Dentistry, Department of Therapeutics Dentistry. Almaty, Kazakh National Medical University named after S.D.Asfendiyarov, Almaty, Kazakhstan
Department of Conservative Dentistry, Jordan University of Science and Technology Irbid, Irbid, Jordan
Department of Endodontics, School of Dentistry, CES University, Medellín, Colombia
Faculty of Dentistry, Tashkent State Dental Institute, Tashkent, Uzbekistan
Faculty of Medicine and Health, Sydney Dental School, The University of Sydney, Sydney, Australia
Central Interdisciplinary Ambulance in the School of Dentistry, University of Münster, Münster, Germany
Department of Restorative and Aesthetic Dentistry, Faculty of Dentistry, Sana’a University, Sana’a, Yemen
Department of Endodontics, Section of Dental Pathology and Therapeutics, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece
Endodontic department of Dentistry, Universidad Central del Ecuador Quito, Quito, Ecuador
Department of cariology and comprehensive care Dentistry, NYU college of Dentistry, New York, United States
Department of Conservative dentistry and Endodontics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India
Department of Endodontic and Operative Dentistry, Faculty of Dentistry, Damascus University, Damascus, Syrian Arab Republic
University of Zagreb School of Dental Medicine, Zagreb, Croatia
Department of Restorative Dentistry, National Dental Centre, Singapore, Singapore
Endodontics Department, Faculty of Dentistry, Ibb University, Ibb, Yemen
Division of Oral and Maxillofacial Radiology, Department of Care Planning and Restorative Sciences, University of Mississippi Medical Center School of Dentistry, Jackson, 39216, MI, United States
Dept.of Diagnostics, Poznan University of Medical Sciences, Poznan, Poland
Department of Conservative Dentistry and Endodontics, University of Benghazi, Benghazi, Libya
Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Institute of Endodontics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Department of Restorative Dentistry, Recep Tayyip Erdogan University, Rize, Turkey
Department of Endodontics
Department of Oral Radiology
Department of Conservative Dentistry and Endodontics
Department of Odontology
School of Dentistry
Department of Conservative Dentistry
Department of Endodontics
Faculty of Dentistry
Faculty of Medicine and Health
Central Interdisciplinary Ambulance in the School of Dentistry
Department of Restorative and Aesthetic Dentistry
Department of Endodontics
Endodontic department of Dentistry
Department of cariology and comprehensive care Dentistry
Department of Conservative dentistry and Endodontics
Department of Endodontic and Operative Dentistry
University of Zagreb School of Dental Medicine
Department of Restorative Dentistry
Endodontics Department
Division of Oral and Maxillofacial Radiology
Dept.of Diagnostics
Department of Conservative Dentistry and Endodontics
Center for Innovation and Research in Oral Sciences (CIROS)
Institute of Endodontics
Department of Restorative Dentistry
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026