Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation
Peronino C. Guerin C.L. Ivak P. Guyonnet L. Chocron R. Detriché G. Latremouille C. Gruest M. Philippe A. Capel A. Pya Y. Martin A.-C. Jansen P. Gendron N. Netuka I. Smadja D.M.
1 November 2022Lippincott Williams and Wilkins
ASAIO Journal
2022#68Issue 11E173 - E178 pp.
The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory status in nine subjects implanted with the A-TAH in kinetics over one year. Laboratory assessment of leukocyte counts, inflammatory cytokines assay, and peripheral blood mononuclear cell collection before and after A-TAH implantation. Leukocyte counts were not significantly modulated according to time after A-TAH implantation (coefficient of the linear mixed effect model with 95% CI, -0.05 (-0.71 to -0.61); p = 0.44). We explored inflammatory cytokine after A-TAH and did not observe, at any time, a modified profile compared to pre-implantation values (all p-values > 0.05). Finally, we compared the distribution of circulating immune cell subpopulations identified based on sequential expression patterns for multiple clusters of differentiation. None of the population explored had significant modulation during the 12-month follow-up (all p-values > 0.05). In conclusion, using a cytokine multiplex assay combined with a flow cytometry approach, we demonstrated the absence of inflammatory signals in peripheral blood over a period of 12 months following A-TAH implantation.
aeson , cytokines , inflammation , leukocytes , total artificial heart , transplantation
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Université de Paris, Innovative Therapies in Haemostasis, INSERM, Paris, France
Hematology and Biosurgical Research Lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France
Carmat SA, Vélizy-Villacoublay, France
Institut Curie, Paris, France
Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Université de Paris, PARCC, INSERM, Emergency Department, AP-HP, Georges Pompidou European Hospital, Paris, France
National Research Cardiac Surgery Center, Nur-Sultan (Astana), Kazakhstan, Kazakhstan
Cardiac Surgery Department, AP-HP, Georges Pompidou European Hospital, Paris, France
Université de Paris
Hematology and Biosurgical Research Lab (Carpentier Foundation)
Carmat SA
Institut Curie
Department of Cardiovascular Surgery
Université de Paris
National Research Cardiac Surgery Center
Cardiac Surgery Department
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