Myeloid-derived suppressor cells in COVID-19: A review
Perfilyeva Y.V. Ostapchuk Y.O. Tleulieva R. Kali A. Abdolla N. Krasnoshtanov V.K. Perfilyeva A.V. Belyaev N.N.
May 2022Academic Press Inc.
Clinical Immunology
2022#238
Coronavirus disease 2019 (COVID-19) is a potentially life-threatening infection characterized by excessive inflammation, coagulation disorders and organ damage. A dysregulated myeloid cell compartment is one of the most striking immunopathologic signatures of this newly emerged infection. A growing number of studies are reporting on the expansion of myeloid cells with immunoregulatory activities in the periphery and airways of COVID-19 patients. These cells share phenotypic and functional similarities with myeloid-derived suppressor cells (MDSCs), which were first described in cancer patients. MDSCs are a heterogeneous population of pathologically activated myeloid cells that exert immunosuppressive activities against mainly effector T cells. The increased frequency of these cells in COVID-19 patients suggests that they are involved in immune regulation during this infection. In this article, we review the current findings on MDSCs in COVID-19 and discuss the complex role of these cells in the immunopathology of COVID-19.
COVID-19 , Immunopathology , Myeloid-derived suppressor cell , SARS-CoV-2
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M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, 86 Dosmukhamedov St., Almaty, 050012, Kazakhstan
Almaty Branch of the National Center for Biotechnology, 14 Zhahanger St., Almaty, 050012, Kazakhstan
Al-Farabi Kazakh National University, 71 Al-Farabi Avenue, Almaty, 050040, Kazakhstan
Kazakh Research Institute of Oncology and Radiology, 91 Abay Ave., Almaty, 050000, Kazakhstan
Institute of General Genetics and Physiology, 93 Al-Farabi Ave., Almaty, 050060, Kazakhstan
Saint-Petersburg Pasteur Institute, 14 Mira St., St. Petersburg, 197101, Russian Federation
M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry
Almaty Branch of the National Center for Biotechnology
Al-Farabi Kazakh National University
Kazakh Research Institute of Oncology and Radiology
Institute of General Genetics and Physiology
Saint-Petersburg Pasteur Institute
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