Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report
Perfilyeva Y.V. Maukayeva S.B. Smail Y.M. Dmitrovskiy A.M. Ostapchuk Y.O. Zhigailov A.V. Nizkorodova A.S. Berdygulova Z.A. Naizabayeva D.A. Perfilyeva A.V. Maltseva E.R. Kamytbekova K.Z. Skiba Y.A.
December 2023BioMed Central Ltd
Journal of Medical Case Reports
2023#17Issue 1
Background: A limited number of studies have described thrombotic complications in pregnant women with COVID-19. Here we report on fatal pulmonary embolism in a pregnant woman with laboratory confirmed SARS-CoV-2 infection. Case presentation: A 28-year-old Kazakh woman was hospitalized with muscle pain, dry cough and a temperature of 37.5 °C at the 29th week of gestation. Upon admission, a blood test demonstrated elevated neutrophil-to-lymphocyte ratio, decreased levels of erythrocytes and hemoglobin, as well as prolonged prothrombin and activated partial thromboplastin time. Within 14 days of admission, she experienced respiratory distress and underwent transfer to the intensive care unit, intubation and a cesarean section. The patient received intravenous antibiotics, antiviral medications, systemic corticosteroids and dual anticoagulation with aspirin and enoxaparin. Death outcome was reported on day 18 of illness despite aggressive supportive care. Histological analysis demonstrated that obstruction of the main pulmonary arthery and disseminated intravascular coagulation were the causes of death. Conclusions: This case demonstrates that in the management of pregnancy and childbirth in patients with suspected or confirmed COVID-19 infection, special attention should be paid to coagulation system parameters and timely appropriate prophylaxis of thromboembolic complications, which has yet to be determined.
COVID-19 , Lethal Outcome , Pregnancy , Pulmonary Artery Embolism
Text of the article Перейти на текст статьи
Almaty Branch of the National Center for Biotechnology, Central Reference Laboratory, 14 Zhahanger St., Almaty, 050054, Kazakhstan
Semey Medical University, 103 Abay Kunanbayev St., Semey, 071400, Kazakhstan
M. Aikimbayev’s National Scientific Center for Especially Dangerous Infections, 14 Zhahanger St., Almaty, 050054, Kazakhstan
Al-Farabi Kazakh National University, 71 Al-Farabi Avenue, Almaty, 050040, Kazakhstan
Institute of Genetics and Cytology, 93 Al-Farabi Avenue, Almaty, 050060, Kazakhstan
South-Kazakhstan Medical Academy, 1 Al-Farabi Avenue, Shymkent, 16001, Kazakhstan
Almaty Branch of the National Center for Biotechnology
Semey Medical University
M. Aikimbayev’s National Scientific Center for Especially Dangerous Infections
Al-Farabi Kazakh National University
Institute of Genetics and Cytology
South-Kazakhstan Medical Academy
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026