Can interventions targeting MDSCs improve the outcome of vaccination in vulnerable populations?
Perfilyeva Y.V. Aquino A.D. Borodin M.A. Kali A. Abdolla N. Ostapchuk Y.O. Tleulieva R. Perfilyeva A.V. Jainakbayev N.T. Sharipov K.O. Belyaev N.N.
2025Taylor and Francis Ltd.
International Reviews of Immunology
2025#44Issue 4196 - 212 pp.
Preventive vaccination is a crucial strategy for controlling and preventing infectious diseases, offering both effectiveness and cost-efficiency. However, despite the widespread success of vaccination programs, there are still certain population groups who struggle to mount adequate responses to immunization. These at-risk groups include but are not restricted to the elderly, overweight individuals, individuals with chronic infections and cancer patients. All of these groups are characterized by persistent chronic inflammation. Recent studies have demonstrated that one of the key players in immune regulation and the promotion of chronic inflammation are myeloid-derived suppressor cells (MDSCs). These cells possess a wide range of immunosuppressive mechanisms and are able to dampen immune responses in both antigen-specific and antigen-nonspecific manner, thus contributing to the establishment and maintenance of an inflammatory environment. Given their pivotal role in immune modulation, there is growing interest in understanding how MDSCs may influence the efficacy of vaccines, particularly in vulnerable populations. In this narrative review, we discuss whether MDSCs are able to regulate vaccine-induced immunity and whether their suppression can potentially enhance vaccine efficacy in vulnerable populations.
Aging , cancer , chronic infection , myeloid-derived suppressor cell , obesity , vaccination
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M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan
Almazov National Medical Research Center, St. Petersburg, Russian Federation
Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russian Federation
Al-Farabi, Kazakh National University, Almaty, Kazakhstan
Institute of Genetics and Physiology, Almaty, Kazakhstan
Kazakh-Russian Medical University, Almaty, Kazakhstan
Saint-Petersburg Pasteur Institute, St. Petersburg, Russian Federation
M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry
Almazov National Medical Research Center
Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences
Al-Farabi
Institute of Genetics and Physiology
Kazakh-Russian Medical University
Saint-Petersburg Pasteur Institute
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