The national and subnational burden of Non-Hodgkin Lymphomas (NHL) in Italy from 1990 to 2023: results from the Global Burden of Disease Study 2023
Passera R. Zamagni G. Fabbro E. Bauckneht M. Carreras G. Falzone L. Gallus S. Vecchia C.L. Ledda C. Maugeri A. Minervini G. Papa M.V. Perna S. Poddighe D. Monasta L.
October 2025Elsevier Ltd
eClinicalMedicine
2025#88
Background: Non-Hodgkin Lymphomas (NHL) are a large group of 70 different oncohematological malignancies. This study investigated the global burden of NHL and its temporal trends from 1990 to 2023, at the Italian national and subnational level (21 regions/provinces). Methods: We used the Global Burden of Disease Study 2023 estimates to describe the NHL age-standardized incidence (ASIR), mortality (ASMR), years lived with disability (ASYLD), years of life lost (ASYLL), disability-adjusted life years (ASDR) rates, the related 1990–2023 crude all-ages and age-standardized annual rate of changes (ARC), as well as the age-standardized mortality-to-incidence ratio (MIR). Finally, the national estimates for NHL were compared to those for the GBD Global and High-middle Socio-Demographic Index (SDI) countries. Findings: In 2023 at the Italian national level, there were 19,000 NHL new cases, 6020 deaths and 118,120 DALYs, whose majority came from YLLs (92.3%). The 1990–2023 ARC for ASIR was stable, overall (0.20; 95% uncertainty interval (UI) −0.34 to 1.06) as well as among females and males. Both the ARC for ASMR (−0.21; −0.34 to −0.07) and ASDR (−0.33; −0.44 to −0.22) declined over time. The MIR notably improved, reducing from 34.3 to 22.8. At the subnational level, the ASIR was stable in all 21 regions, while the ASMR and ASDR showed a significant decline in 12 and 19 regions, respectively. Interpretation: The age-standardized deaths and DALYs rates due to NHL significantly decreased over time in Italy, while the incidence rate was stable. Increased early detection, new therapeutic regimens availability and risk factors pattern modification might justify these findings. Comparing the national estimates to those for the High-middle SDI region, the ARC for incidence, mortality, YLLs and DALYs showed a larger improvement. Italian subnational estimates were in good agreement with the national data, with some geographical differences. Funding: This work was supported by the Italian Ministry of Health, through the contribution given to the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste - Italy.
DALYs , Disability , Global Burden of Disease Study 2021 , Incidence , Mortality , Non Hodgkin’s lymphoma (NHL) , Risk factors
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Department of Medical Sciences, University of Torino, Torino, Italy
Department of Imaging, AOU Città della Salute e della Scienza di Torino, Torino, Italy
Clinical Epidemiology and Public Health Research Unit, Italy
Burlo Garofolo Institute for Maternal and Child Health, Trieste, Italy
Institute for Research and Innovative Technologies Area Science Park, Trieste, Italy
Department of Health Sciences (DISSAL), University of Genoa, Genova, Italy
Department of Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genova, Italy
Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, Italy
Epidemiology and Biostatistics Unit, IRCCS Pascale, Naples, Italy
Department of Medical Epidemiology Mario Negri Institute for Pharmacological Research, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy
Saveetha Dental College, Hospitals Saveetha University, Chennai, India
University of Padua, Padua, Italy
Department of Food, Environmental and Nutritional Sciences University of Milan, Milano, Italy
College of Health Sciences (CHS) VinUniversity, Hanoi, Viet Nam
Clinical Academic Department of Pediatrics, University Medical Center (UMC), Astana, Kazakhstan
Department of Medical Sciences
Department of Imaging
Clinical Epidemiology and Public Health Research Unit
Burlo Garofolo Institute for Maternal and Child Health
Institute for Research and Innovative Technologies Area Science Park
Department of Health Sciences (DISSAL)
Department of Nuclear Medicine
Institute for Cancer Research
Department of Biomedical and Biotechnological Sciences
Department of Clinical and Experimental Medicine
Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia
Epidemiology and Biostatistics Unit
Department of Medical Epidemiology Mario Negri Institute for Pharmacological Research
Department of Clinical Sciences and Community Health
Multidisciplinary Department of Medical-Surgical and Dental Specialties
Saveetha Dental College
University of Padua
Department of Food
College of Health Sciences (CHS) VinUniversity
Clinical Academic Department of Pediatrics
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