Synthesis, Structure, and Hemorheological Activity of Pentasubstituted Cyclohexanol
Palamarchuk I.V. Shulgau Z.T. Sergazy S.D. Zhulikeeva A.M. Gatilov Y.V. Kulakov I.V.
December 2021Pleiades journals
Russian Journal of General Chemistry
2021#91Issue 122462 - 2468 pp.
Abstract: The intramolecular condensation of chalcone (benzylideneacetophenone) in a DMSO solution in the presence of KOH gave (4-hydroxy-2,4,6-triphenylcyclohexane-1,3-diyl)bis(phenylmethanone). Structure of the synthesized derivative was proved by 1H, 13C NMR spectroscopy, mass spectrometry and X-ray diffraction analysis. The obtained cyclohexanol derivative shows hemorheological activity: it is able to inhibit the growth of the viscosity of whole blood during the formation of the syndrome of increased blood viscosity in vitro.
chalcone , cyclohexanol derivative , hemorheological activity , intramolecular cyclization , Michael reaction , X-ray diffraction analysis
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Tyumen State University, Tyumen, 625003, Russian Federation
Republican State Enterprise “National Center for Biotechnology”, Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan, Nur-Sultan, 010000, Kazakhstan
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
Tyumen State University
Republican State Enterprise “National Center for Biotechnology”
Vorozhtsov Novosibirsk Institute of Organic Chemistry
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