Biological Roles and Prospects of using Adipose Tissue Derivatives and Platelet-Rich Plasma in Surgical Practice: A Review
Pak I. Askarov M. Klyuyev D. Tak M.S. Batenova U. Yeskermessov D. Feoktistov V. Kamyshanskiy Y.
2025Bentham Science Publishers
Open Biomedical Engineering Journal
2025#19
Adipose tissue and platelet-rich plasma (PRP) have gained significant attention in regenerative medicine and plastic surgery due to their potential in tissue repair and wound healing. This review aimed to analyze the biological properties of adipose tissue, lipofilling techniques, and the role of PRP in enhancing fat graft survival and tissue regeneration. A comprehensive review of the literature was carried out to evaluate the cellular composition, regenerative mechanisms, and clinical applications of adipose-derived therapies and PRP. Adipose tissue contains multipotent stem cells that contribute to angiogenesis, immunomodulation, and tissue remodeling. PRP enhances fat graft retention by promoting vascularization and reducing inflammatory responses. The combined use of PRP and adipose tissue has shown promising outcomes in wound healing, plastic surgery, and reconstructive procedures. The integration of adipose tissue derivatives and PRP holds significant potential for improving surgical outcomes. However, further research is needed to standardize protocols, optimize therapeutic strategies, and ensure reproducible clinical benefits.
Adipose tissue , Adipose-derived stem cells , Angiogenesis , Anti-inflammatory properties , Autologous fat grafting , Extracellular matrix , Fat grafting , Graft survival , Lipofilling , Plastic surgery , Platelet-rich plasma (PRP) , PRP preparation methods , Regenerative medicine , Stem cells , Tissue regeneration , Wound healing
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Department Plastic surgery, Karaganda State Medical University, Karaganda, Kazakhstan
Department Life Science Institute, Karaganda State Medical University, Karaganda, Kazakhstan
Department Plastic surgery, Soon Chun Hyang University Cheonan Hospital, Cheonan, South Korea
Department Traumatology, Karaganda State Medical University, Karaganda, Kazakhstan
Department Pathology, Karaganda State Medical University, Karaganda, Kazakhstan
Department Plastic surgery
Department Life Science Institute
Department Plastic surgery
Department Traumatology
Department Pathology
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