Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.
Painuli S. Quispe C. Herrera-Bravo J. Semwal P. Martorell M. Almarhoon Z.M. Seilkhan A. Ydyrys A. Rad J.S. Alshehri M.M. Daştan S.D. Taheri Y. Calina D. Cho W.C.
2022Hindawi Limited
Oxidative Medicine and Cellular Longevity
2022#2022
The roots, leaves, and seeds of Lepidium sativum L., popularly known as Garden cress in different regions, have high economic importance; although, the crop is particularly cultivated for the seeds. In traditional medicine, this plant has been reported to possess various biological activities. This review is aimed at providing updated and critical scientific information about the traditional, nutritional, phytochemical, and biological activities of L. sativum. In addition, the geographic distribution is also reviewed. The comprehensive literature search was carried out with the help of different search engines PubMed, Web of Science, and Science Direct. This review highlighted the importance of L. sativum as an edible herb that possesses a wide range of therapeutic properties along with high nutritional values. Preclinical studies (in vitro and in vivo) displayed anticancer, hepatoprotective, antidiabetic, hypoglycemic, antioxidant, antimicrobial, gastrointestinal, and fracture/bone healing activities of L. sativum and support the clinical importance of plant-derived bioactive compounds for the treatment of different diseases. Screening of literature revealed that L. sativum species and their bioactive compounds may be a significant source for new drug compounds and also could be used against malnutrition. Further clinical trials are needed to effectively assess the actual potential of the species and its bioactive compounds.
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Himalayan Environmental Studies and Conservation Organization, Uttarakhand, Dehradun, 248006, India
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de la Frontera, Temuco, 4811230, Chile
Department of Life Sciences, Graphic Era Deemed to Be University, Uttarakhand, Dehradun, 248 002, India
Department of Nutrition and Dietetics, Faculty of Pharmacy and Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia
Educational Program, Geography, Environment and Service Sector, Abai Kazakh National Pedagogical University, Almaty, Kazakhstan
Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Himalayan Environmental Studies and Conservation Organization
Facultad de Ciencias de la Salud
Departamento de Ciencias Básicas
Center of Molecular Biology and Pharmacogenetics
Department of Life Sciences
Department of Nutrition and Dietetics
Department of Chemistry
Educational Program
Biomedical Research Centre
Phytochemistry Research Center
Pharmaceutical Care Department
Department of Biology
Beekeeping Development Application and Research Center
Department of Clinical Pharmacy
Department of Clinical Oncology
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