Effects of internal exposure to neutron-activated 56MnO2powder on locomotor activity in rats
Otani K. Ohtaki M. Fujimoto N. Uzbekov D. Kairkhanova Y. Saimova A. Chaizhunusova N. Habdarbaeva D. Azhimkhanov A. Zhumadilov K. Stepanenko V. Hoshi M.
1 September 2022Oxford University Press
Journal of Radiation Research
2022#63I38 - I44 pp.
At the detonation of the atomic bombing in Hiroshima and Nagasaki, a significant amount of radionuclides was produced by the neutron induced activation. The residual radiation from the explosion is crucial to the health risk of the people who entered these cities after the bombing and might have inhaled these radioactive materials. Because 56Mn is one of the major radionuclides produced in soil and have not been studied until now, we had conducted a series of experiments using rats to investigate the biological impacts of exposure of 56MnO2 particles. In these experiments, the rats spontaneous locomotor activity was also assessed to examine the possible effects of 56Mn on their behavior. However, the locomotor activity data obtained from an individual experiment failed to identify radiation effects due to the large variation among animals and the small sample size. In the present study, all available data from our previous studies on 56MnO2 exposure (0.02-0.15 Gy of whole-body doses) as well as 60Co-γexposure (at 2-5 Gy of whole-body doses) were pooled. Our statistical method, which takes into account individual differences and daily fluctuations, successfully identified a decrease in locomotor activity caused by 56MnO2 exposure, where the changes were gradual and reached the maximum reduction around 2 weeks after exposure. In contrast, exposure to 60Co-γrays produced the highest decline of activity within one day. These results suggest that internal exposure to 56Mn at whole-body doses of even less than 0.15 Gy may have a long-lasting impact on locomotor activity.
56MnO2microparticles , fluctuations , individual differences , internal exposure , linear mixed effect model , locomotor activities
Text of the article Перейти на текст статьи
The Center for Peace Hiroshima University, Hiroshima, 730-0053, Japan
Hiroshima University, 739-8527, Japan
Semey State Medical University, Semey, 071400, Kazakhstan
National Nuclear Center of the Republic of Kazakhstan, Kazakhstan, 490021, Kazakhstan
Eurasian National University named after L.N. Gumilyov, Kazakhstan, 010008, Kazakhstan
Tsyb Medical Radiological Research Center, Obninsk, 2490031, Russian Federation
Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, 734-8553, Japan
The Center for Peace Hiroshima University
Hiroshima University
Semey State Medical University
National Nuclear Center of the Republic of Kazakhstan
Eurasian National University named after L.N. Gumilyov
Tsyb Medical Radiological Research Center
Research Institute for Radiation Biology and Medicine
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026