Activity against SARS-CoV-2 of Various Anionic Disinfectants and Their Complexes with Hydrophobically Modified Chitosan
Ospennikov A.S. Kornilaeva G.V. Larichev V.F. Fedyakina I.T. Fu L. Chen Z. Yang Y. Shibaev A.V. Karamov E.V. Turgiev A.S. Duan L. Liu W.J. Philippova O.E.
2023E.A. Buketov Karaganda University Publish house
Eurasian Journal of Chemistry
2023#2023Issue 251 - 58 pp.
The aim of this work was to study virucidal activity against SARS-CoV-2 of several anionic disinfectants, which are antiseptics recommended by the U.S. Environmental Protection Agency (EPA), and to prepare their complexes with hydrophobically modified chitosan active against SARS-CoV-2. Experiments were performed using a clinical isolate of SARS-CoV-2 obtained from a patient in 2020. It was shown that sodium dodecyl benzene sulfonate (SDBS) is already active at rather small concentrations (above 2 mM), which completely deactivate the virus. In the same concentration range, sodium caprylate does not show activity; and sodium lactate is active against SARS-CoV-2 only at much higher concentrations (225 mM). The most effective disinfectant — sodium dodecylbenzene sulfonate — was used to prepare complexes with hydrophobically modified chitosan. It was found that such complexes exhibit antiviral activity at very low concentrations (1.9 mM chitosan monomer units and 0.25 mM SDBS), at which the polymer without surfac-tant is not active against SARS-CoV-2.
anionic disinfectants , chitosan , hydrophobic modification , polymer/surfactant complexes , SARS-CoV-2 , sodium caprylate , sodium dodecyl benzene sulfonate , sodium lactate
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Department of Physics, Lomonosov Moscow State University, Moscow, Russian Federation
Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, Moscow, Russian Federation
CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China
Shanghai Key Laboratory of Chemical Biology, Shanghai key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
Karagandy University of the name of academician E.A. Buketov, Karaganda, Kazakhstan
National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health, Moscow, Russian Federation
NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
Department of Physics
Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health
CAS Key Laboratory of Pathogen Microbiology and Immunology
Shanghai Key Laboratory of Chemical Biology
Karagandy University of the name of academician E.A. Buketov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health
NHC Key Laboratory of Parasite and Vector Biology
NHC Key Laboratory of Biosafety
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