H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos
Osipov Y.A. Posukh O.V. Kalashnikova D.A. Antoshina P.A. Laktionov P.P. Skrypnik P.A. Belyakin S.N. Singh P.B.
November 2023Springer Science and Business Media Deutschland GmbH
Chromosoma
2023#132Issue 4317 - 328 pp.
Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococcus citri H3K9 and H4K20 histone methyl transferases (HMTases) in regulating heterochromatinization of the imprinted paternal chromosomal set in male embryos. We found that H3K9 and H420 HMTases are required for heterochromatinization of the paternal chromosomes. We present evidence that both HMTases maintain the paternal “imprint” during the cleavage divisions when both parental chromosome sets are euchromatic. A testable model that accommodates our findings is proposed.
Epigenetics , Genomic imprinting , H3K9me3:HP1:H4K20me3 pathway , Heterochromatin
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Epigenetics Laboratory, Department of Natural Sciences, Novosibirsk State University, Pirogov Str. 2, Novosibirsk, 630090, Russian Federation
Institute of Molecular and Cellular Biology SD RAS, Lavrentyev Ave., 8/2, Novosibirsk, 630090, Russian Federation
Nazarbayev University School of Medicine, 5/1 Kerei, Zhanibek Khandar Street, Nur-Sultan, 010000, Kazakhstan
Epigenetics Laboratory
Institute of Molecular and Cellular Biology SD RAS
Nazarbayev University School of Medicine
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