Overweight effects on metabolic rate, time perception, diseases, aging, and lifespan: A systematic review with meta-regression analysis
Oshakbayev K. Durmanova A. Nabiyev A. Sarria-Santamera A. Idrissov A. Bedelbayeva G. Gaipov A. Mitra A. Gazaliyeva M. Dukenbayeva B. Kuttymuratov G.
January 2025KeAi Communications Co.
Translational Medicine of Aging
2025#915 - 24 pp.
Background: The hypothesis that metabolic rate (MR) is inversely correlated with lifespan has long been debating. Another area of controversy is the relationship between MR and time-flow perception (TFP), and aging. Objectives: to study the impact of overweight and excess food intake on MR, TFP, chronic diseases, aging, lifespan. Methods: Design: a systematic review. Settings: Web of Science, Scopus, Science Direct, Kopernio, PubMed, and Mendeley were searched for articles published for 44 years (1979–2022). The study bases on a systematic literature review of 3612 articles published worldwide. Results: In total, 107 full-text articles were assessed for eligibility. Overweight/overeating accelerates MR, leading to a hyper-metabolic mode of the body. MR and lifespan are inversely correlated. TFP depends on MR; accelerated MR provides TFP deceleration. Every person has an individual ability to gain weight up to ‘maximum bodyweight’, which indicates the individual potential energy for weight gain. Overweight excessively consumes the bodys ‘vital energy’, and devours the body potential energy. Weight loss creates ‘body potential power to weight gain’ that increases physical/mental activity, recovers from disease, or weight regain. The body should consume fewer calories due the decline in MR with age. Conclusions: Our findings support that overweight and overeating increase in MR, which delays time-flow perception, accelerates aging, and limits lifespan. Metabolic intoxication should be managed during weight loss. Trial registration: ClinicalTrials.gov NCT06410352 (05/08/2024): https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000EG8K&selectaction=Edit&uid=U0006MBT&ts=56&cx=-vph5l9.
Aging , Lifespan , Metabolic rate , Obesity paradox , Overweight , Time-flow perception , Weight gain body potential energy
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University medical center, Clinical Academic Department Internal Medicine, Syganak str., 46, Astana, 010000, Kazakhstan
Nazarbayev University, School of Medicine, Dept Med, Kerey & Zhanibek St 5-1, Astana, 010000, Kazakhstan
Astana Medical University, Department of Family Medicine, Street Beibitshilik 49a, Astana city, Kazakhstan
Asfendiyarov Kazakh National Medical University, Faculty of postgraduate education, Street Tole Bi, 94, Almaty city, 050000, Kazakhstan
Inter-University Centre for Astronomy and Astrophysics, Savitribai Phule Pune University, Post Bag 4, Ganeshkhind, Maharashtra, Pune, 411007, India
Astana Medical University, Faculty of Internal Medicine, Street Beibitshilik St 49/A, Astana city, Kazakhstan
Astana Medical University, Faculty of pathology and forensic medicine, Astana, Kazakhstan
University medical center, Department urology and kidney transplantation, Turan avenue 32, Astana, 010000, Kazakhstan
ANADETO’ medical center, Street Kerey Zhanibek Khans, 22, Astana, 010000, Kazakhstan
University medical center
Nazarbayev University
Astana Medical University
Asfendiyarov Kazakh National Medical University
Inter-University Centre for Astronomy and Astrophysics
Astana Medical University
Astana Medical University
University medical center
ANADETO’ medical center
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