Correction of liver changes caused by alcohol rates with probiotics

Orynbayeva Z. Tungushbayeva Z. Nurlybayeva K. Abikenova F. Jankiewicz U. Seilkhan A. Koibasova L. Kurmanbay U.
October 2024 University of Guilan

Caspian Journal of Environmental Sciences
2024 #22 Issue 4 993 - 998 pp.

There is evidence of the beneficial effects of probiotics in fatty liver cases. This study aims to evaluate the effects of probiotic intake on several metabolic factors in people with fatty liver. Eighty patients with fatt y liver with a body mass index above 25 were divided into three groups: the control group, the alcohol group, and the probiotic group. After 45 days, fasting blood samples, physical changes, and dietary intakes were measured over the experiment. Statistical analysis was performed with SPSS software, and variance analysis was done. Significant reduction in weight (4%) and BMI (5%) was observed (p-value less than 0.001). The percent changes in weight and BMI were at a rate of 4.8% compared to the control group. The waist circumference in both groups showed a significant difference after the intervention, with the probiotic group decreasing by 8% compared to the control group. The findings showed that probiotic treatment was beneficial in reducing the severity of liver damage, most likely through increasing beneficial bacteria and reducing inflammatory responses and oxidative stress, and led to weight loss and BMI.

Adipokines , Alcohol , Fatty Liver , Probiotic

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Abai Kazakh National Pedagogical University, Faculty of Natural Sciences and Geography, Almaty, Kazakhstan
Karaganda Buketov University, Karaganda, Kazakhstan
Department of Physiology, NP JSC “Karaganda Medical University”, Karaganda, Kazakhstan
Warsaw University of Life Sciences, Biochemistry and Microbiology Department, Institute of Biology, Warsaw, Poland
Institute of Genetics and Physiology, MS MHES RK, Almaty, Kazakhstan
Department of Chemistry and Biology, Faculty of Pedagogical and Natural Sciences, Zh. Tashenev university, Shymkent, Kazakhstan

Abai Kazakh National Pedagogical University
Karaganda Buketov University
Department of Physiology
Warsaw University of Life Sciences
Institute of Genetics and Physiology
Department of Chemistry and Biology

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