Recapping the Features of SARS-CoV-2 and Its Main Variants: Status and Future Paths

Ortega M.A. García-Montero C. Fraile-Martinez O. Colet P. Baizhaxynova A. Mukhtarova K. Alvarez-Mon M. Kanatova K. Asúnsolo A. Sarría-Santamera A.
June 2022 MDPI

Journal of Personalized Medicine
2022 #12 Issue 6

Over the two years that we have been experiencing the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic, our challenges have been the race to develop vaccines and the difficulties in fighting against new variants due to the rapid ability of the virus to evolve. In this sense, different organizations have identified and classified the different variants that have been emerging, distinguishing between variants of concern (VOC), variants of interest (VOI), or variants under monitoring (VUM). The following review aims to describe the latest updates focusing on VOC and already de-escalated variants, as well as to describe the impact these have had on the global situation. Understanding the intrinsic properties of SARS-CoV-2 and its interaction with the immune system and vaccination is essential to make out the underlying mechanisms that have led to the appearance of these variants, helping to determine the next steps for better public management of this pandemic.

COVID-19 , de-escalation , epidemiology , SARS-CoV-2 , variants , VOC , VOI

Text of the article Перейти на текст статьи

Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, 28801, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, 28034, Spain
Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan, 010000, Kazakhstan
Immune System Diseases-Rheumatology, Oncology Service an Internal Medicine (CIBEREHD), University Hospital Príncipe de Asturias, Alcala de Henares, 28806, Spain
Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, 28801, Spain

Department of Medicine and Medical Specialities
Ramón y Cajal Institute of Sanitary Research (IRYCIS)
Department of Medicine
Immune System Diseases-Rheumatology
Department of Surgery

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026