Granulomatosis with Polyangiitis with Ocular Manifestations

Orazbekov L. Issergepova B. Assainova M. Ruslanuly K.
January 2021 S. Karger AG

Case Reports in Ophthalmology
2021 #12 Issue 1 98 - 104 pp.

Granulomatosis with polyangiitis (GPA) is a granulomatous-necrotic systemic vasculitis with a lesion of predominantly the upper and lower respiratory tracts at the onset of the disease (vasculitis, accompanied by granulomatous inflammation), and subsequently renal (glomerulonephritis). In addition, GPA may manifest as inflammation of small arteries and veins. Despite many years of study of this disease, the etiology of GPA remains unknown. The present case is about a 47-year-old female, who had been suffering from necrotizing scleritis, corneal ulcer, and secondary glaucoma in both eyes for 3 months, and she was treated with anti-inflammatory and antimicrobial therapy that showed no effect; the patients general condition became worse. In the second week of treatment, multiple abscess ruptures exposed the sclera. Sampling of the affected conjunctival tissue and positive HLA B8 haplotype and ANCA (PR3-ANCA) testings make it clear that GPA was the main reason of necrotizing scleritis with inflammation. The targeted treatment of the underlying disease allows to stabilize an inflammation of corneal and scleral lesions.

Corneal ulcer , Granulomatosis with polyangiitis , Necrotizing scleritis , Wegeners granulomatosis

Text of the article Перейти на текст статьи

First Ophthalmology Department, Kazakh Eye Research Institute, Almaty, Kazakhstan
Postgraduate Education Department, Kazakh Eye Research Institute, Almaty, Kazakhstan
Fourth Ophthalmology Department, Kazakh Eye Research Institute, Almaty, Kazakhstan

First Ophthalmology Department
Postgraduate Education Department
Fourth Ophthalmology Department

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026