Potential applicability of polyethyleneimine PEI-coated Eu2O3and Dy2O3nanoparticles for contrast enhancement in computed tomography
Olifirenko V. Abduraimova A. Kang M.S. Raja I.S. Duisenbayeva B. Molkenova A. Khamkhash L. Hwang Y.-H. Han D.-W. Atabaev T.S.
1 March 2021Institute of Physics
Nano Express
2021#2Issue 1
Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to investigate the potential applicability of polyethyleneimine (PEI)-coated Eu2O3 and Dy2O3 nanoparticles (NPs) for CT x-ray attenuation. Morphology and other physicochemical properties of prepared samples were systematically investigated using a range of characterization tools. Preliminary cytotoxicity experiments with L-929 fibroblastic cells suggested that both samples have no significant toxicity at concentrations below 100 μg ml-1. Clinical CT analysis shows that PEI@Eu2O3 NPs exhibit higher x-ray attenuation efficiency (∼8 HU mM-1) as compared to PEI@Dy2O3 NPs (∼5 HU mM-1).
CT contrast agents , cytotoxicity , Dy2O3 , Eu2O3 , nanoparticles , polyethyleneimine
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Department Of Biology, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department Of Cogno-Mechatronics Engineering, College Of Nanoscience And Nanotechnology, Pusan National University, Busan, 46241, South Korea
Department Of Radiology, Green Clinic, Nur-Sultan, 010000, Kazakhstan
Department Of Chemistry, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Core Facilities, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department Of Nanoenergy Engineering, BK21 Plus Nanoconvergence Technology Division, Pusan National University, Busan, 46241, South Korea
Department Of Biology
Department Of Cogno-Mechatronics Engineering
Department Of Radiology
Department Of Chemistry
Core Facilities
Department Of Nanoenergy Engineering
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